Pritchard J - Search Results

1

How soluble misfolded proteins bypass chaperones at the molecular level.

Halder R, Nissley DA, Sitarik I, Jiang Y, Rao Y, Vu QV, Li MS, Pritchard J, O'Brien EP. Halder R, et al. Among authors: pritchard j. Nat Commun. 2023 Jun 21;14(1):3689. doi: 10.1038/s41467-023-38962-z. Nat Commun. 2023. PMID: 37344452 Free PMC article.

2

Genomic and experimental evidence that ALK^ATI does not predict single agent sensitivity to ALK inhibitors.

Inam H, Sokirniy I, Rao Y, Shah A, Naeemikia F, O'Brien E, Dong C, McCandlish DM, Pritchard JR. Inam H, et al. iScience. 2021 Oct 26;24(11):103343. doi: 10.1016/j.isci.2021.103343. eCollection 2021 Nov 19. iScience. 2021. PMID: 34825133 Free PMC article.

3

A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments.

Zhao B, Rao Y, Leighow S, O'Brien EP, Gilbert L, Pritchard JR. Zhao B, et al. Nat Commun. 2022 Feb 2;13(1):625. doi: 10.1038/s41467-022-28045-w. Nat Commun. 2022. PMID: 35110534 Free PMC article.

4

Programming tumor evolution with selection gene drives to proactively combat drug resistance.

Leighow SM, Reynolds JA, Sokirniy I, Yao S, Yang Z, Inam H, Wodarz D, Archetti M, Pritchard JR. Leighow SM, et al. Nat Biotechnol. 2024 Jul 4. doi: 10.1038/s41587-024-02271-7. Online ahead of print. Nat Biotechnol. 2024. PMID: 38965430

5

The risks of perpetuating an evolutionary arms race in drug discovery.

Leighow SM, Pritchard JR. Leighow SM, et al. Evol Med Public Health. 2019 May 21;2019(1):64-65. doi: 10.1093/emph/eoz013. eCollection 2019. Evol Med Public Health. 2019. PMID: 31186898 Free PMC article. No abstract available.

6

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.

Bruno PM, Liu Y, Park GY, Murai J, Koch CE, Eisen TJ, Pritchard JR, Pommier Y, Lippard SJ, Hemann MT. Bruno PM, et al. Among authors: pritchard jr. Nat Med. 2017 Apr;23(4):461-471. doi: 10.1038/nm.4291. Epub 2017 Feb 27. Nat Med. 2017. PMID: 28263311 Free PMC article.

7

Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design.

Leighow SM, Liu C, Inam H, Zhao B, Pritchard JR. Leighow SM, et al. Cell Rep. 2020 Mar 24;30(12):3951-3963.e4. doi: 10.1016/j.celrep.2020.02.108. Cell Rep. 2020. PMID: 32209458 Free PMC article.

8

The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.

Bruno PM, Lu M, Dennis KA, Inam H, Moore CJ, Sheehe J, Elledge SJ, Hemann MT, Pritchard JR. Bruno PM, et al. Among authors: pritchard jr. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4053-4060. doi: 10.1073/pnas.1921649117. Epub 2020 Feb 10. Proc Natl Acad Sci U S A. 2020. PMID: 32041867 Free PMC article.

9

Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes.

Leighow SM, Landry B, Lee MJ, Peyton SR, Pritchard JR. Leighow SM, et al. Among authors: pritchard jr. Cell Mol Bioeng. 2022 Nov 15;15(5):521-533. doi: 10.1007/s12195-022-00748-6. eCollection 2022 Oct. Cell Mol Bioeng. 2022. PMID: 36444351 Free PMC article.

10

Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing.

Liu C, Leighow SM, McIlroy K, Lu M, Dennis KA, Abello K, Brown DJ, Moore CJ, Shah A, Inam H, Rivera VM, Pritchard JR. Liu C, et al. Among authors: pritchard jr. Cell Rep Med. 2023 Oct 17;4(10):101227. doi: 10.1016/j.xcrm.2023.101227. Cell Rep Med. 2023. PMID: 37852183 Free PMC article.

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