Levy C - Search Results

1

Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site.

Kalvet I, Ortmayer M, Zhao J, Crawshaw R, Ennist NM, Levy C, Roy A, Green AP, Baker D. Kalvet I, et al. Among authors: levy c. J Am Chem Soc. 2023 Jul 5;145(26):14307-14315. doi: 10.1021/jacs.3c02742. Epub 2023 Jun 21. J Am Chem Soc. 2023. PMID: 37341421 Free PMC article.

2

Design and evolution of an enzyme with a non-canonical organocatalytic mechanism.

Burke AJ, Lovelock SL, Frese A, Crawshaw R, Ortmayer M, Dunstan M, Levy C, Green AP. Burke AJ, et al. Among authors: levy c. Nature. 2019 Jun;570(7760):219-223. doi: 10.1038/s41586-019-1262-8. Epub 2019 May 27. Nature. 2019. PMID: 31132786

3

Rewiring the "Push-Pull" Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code.

Ortmayer M, Fisher K, Basran J, Wolde-Michael EM, Heyes DJ, Levy C, Lovelock SL, Anderson JLR, Raven EL, Hay S, Rigby SEJ, Green AP. Ortmayer M, et al. Among authors: levy c. ACS Catal. 2020 Feb 21;10(4):2735-2746. doi: 10.1021/acscatal.9b05129. Epub 2020 Jan 29. ACS Catal. 2020. PMID: 32550044 Free PMC article.

4

A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase.

Ortmayer M, Hardy FJ, Quesne MG, Fisher K, Levy C, Heyes DJ, Catlow CRA, de Visser SP, Rigby SEJ, Hay S, Green AP. Ortmayer M, et al. Among authors: levy c. JACS Au. 2021 Jul 26;1(7):913-918. doi: 10.1021/jacsau.1c00145. Epub 2021 May 14. JACS Au. 2021. PMID: 34337604 Free PMC article.

5

Engineering an efficient and enantioselective enzyme for the Morita-Baylis-Hillman reaction.

Crawshaw R, Crossley AE, Johannissen L, Burke AJ, Hay S, Levy C, Baker D, Lovelock SL, Green AP. Crawshaw R, et al. Among authors: levy c. Nat Chem. 2022 Mar;14(3):313-320. doi: 10.1038/s41557-021-00833-9. Epub 2021 Dec 16. Nat Chem. 2022. PMID: 34916595 Free PMC article.

6

The road to fully programmable protein catalysis.

Lovelock SL, Crawshaw R, Basler S, Levy C, Baker D, Hilvert D, Green AP. Lovelock SL, et al. Among authors: levy c. Nature. 2022 Jun;606(7912):49-58. doi: 10.1038/s41586-022-04456-z. Epub 2022 Jun 1. Nature. 2022. PMID: 35650353 Review.

7

A designed photoenzyme for enantioselective [2+2] cycloadditions.

Trimble JS, Crawshaw R, Hardy FJ, Levy CW, Brown MJB, Fuerst DE, Heyes DJ, Obexer R, Green AP. Trimble JS, et al. Nature. 2022 Nov;611(7937):709-714. doi: 10.1038/s41586-022-05335-3. Epub 2022 Sep 21. Nature. 2022. PMID: 36130727

8

Probing Ferryl Reactivity in a Nonheme Iron Oxygenase Using an Expanded Genetic Code.

Hardy FJ, Quesne MG, Gérard EF, Zhao J, Ortmayer M, Taylor CJ, Ali HS, Slater JW, Levy CW, Heyes DJ, Bollinger JM Jr, de Visser SP, Green AP. Hardy FJ, et al. ACS Catal. 2024 Jul 20;14(15):11584-11590. doi: 10.1021/acscatal.4c02365. eCollection 2024 Aug 2. ACS Catal. 2024. PMID: 39114090 Free PMC article.

9

Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction.

Pudney CR, Hay S, Levy C, Pang J, Sutcliffe MJ, Leys D, Scrutton NS. Pudney CR, et al. Among authors: levy c. J Am Chem Soc. 2009 Dec 2;131(47):17072-3. doi: 10.1021/ja908469m. J Am Chem Soc. 2009. PMID: 19891489

10

Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes.

Knaus T, Paul CE, Levy CW, de Vries S, Mutti FG, Hollmann F, Scrutton NS. Knaus T, et al. J Am Chem Soc. 2016 Jan 27;138(3):1033-9. doi: 10.1021/jacs.5b12252. Epub 2016 Jan 13. J Am Chem Soc. 2016. PMID: 26727612 Free PMC article.

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