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Coronaridine congeners induce sedative and anxiolytic-like activity in naïve and stressed/anxious mice by allosteric mechanisms involving increased GABAA receptor affinity for GABA.
Arias HR, De Deurwaerdère P, Scholze P, Sakamoto S, Hamachi I, Di Giovanni G, Chagraoui A. Arias HR, et al. Among authors: de deurwaerdere p. Eur J Pharmacol. 2023 Aug 15;953:175854. doi: 10.1016/j.ejphar.2023.175854. Epub 2023 Jun 16. Eur J Pharmacol. 2023. PMID: 37331683
The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation.
Arias HR, Rudin D, Hines DJ, Contreras A, Gulsevin A, Manetti D, Anouar Y, De Deurwaerdere P, Meiler J, Romanelli MN, Liechti ME, Chagraoui A. Arias HR, et al. Among authors: de deurwaerdere p. Eur J Pharmacol. 2024 Mar 5;966:176329. doi: 10.1016/j.ejphar.2024.176329. Epub 2024 Jan 20. Eur J Pharmacol. 2024. PMID: 38253116
The psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naïve and depressed mice by mechanisms involving 5-HT2A receptor activation and serotonergic transmission.
Arias HR, Rudin D, Luethi D, Valenta J, Leśniak A, Czartoryska Z, Olejarz-Maciej A, Doroz-Płonka A, Manetti D, De Deurwaerdère P, Romanelli MN, Handzlik J, Liechti ME, Chagraoui A. Arias HR, et al. Among authors: de deurwaerdere p. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Dec 9;136:111217. doi: 10.1016/j.pnpbp.2024.111217. Online ahead of print. Prog Neuropsychopharmacol Biol Psychiatry. 2024. PMID: 39662723
Neurochemical Databases: Purpose and Expectations.
Butler JJ, Parrot S, Aman C, De Deurwaerdère P. Butler JJ, et al. Among authors: de deurwaerdere p. ACS Chem Neurosci. 2025 Jan 15;16(2):108-110. doi: 10.1021/acschemneuro.4c00812. Epub 2024 Dec 31. ACS Chem Neurosci. 2025. PMID: 39737796
Classical psychedelics' action on brain monoaminergic systems.
Butler JJ, Ricci D, Aman C, Beyeler A, De Deurwaerdère P. Butler JJ, et al. Among authors: de deurwaerdere p. Int J Biochem Cell Biol. 2024 Nov;176:106669. doi: 10.1016/j.biocel.2024.106669. Epub 2024 Sep 25. Int J Biochem Cell Biol. 2024. PMID: 39332625 Review.
Serotonergic neurons are involved in the counter-regulatory response to hypoglycemia.
Martin H, Coursan A, Lallement J, Di Miceli M, Kandiah J, Raho I, Buttler J, Guilloux JP, De Deurwaerdere P, Layé S, Routh VH, Guiard BP, Magnan C, Cruciani-Guglielmacci C, Fioramonti X. Martin H, et al. Among authors: de deurwaerdere p. J Neuroendocrinol. 2023 Dec;35(12):e13344. doi: 10.1111/jne.13344. Epub 2023 Oct 19. J Neuroendocrinol. 2023. PMID: 37857383
138 results