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The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation.
Arias HR, Rudin D, Hines DJ, Contreras A, Gulsevin A, Manetti D, Anouar Y, De Deurwaerdere P, Meiler J, Romanelli MN, Liechti ME, Chagraoui A. Arias HR, et al. Eur J Pharmacol. 2024 Mar 5;966:176329. doi: 10.1016/j.ejphar.2024.176329. Epub 2024 Jan 20. Eur J Pharmacol. 2024. PMID: 38253116
The psychoplastogens ibogaminalog and ibogainalog induce antidepressant-like activity in naïve and depressed mice by mechanisms involving 5-HT2A receptor activation and serotonergic transmission.
Arias HR, Rudin D, Luethi D, Valenta J, Leśniak A, Czartoryska Z, Olejarz-Maciej A, Doroz-Płonka A, Manetti D, De Deurwaerdère P, Romanelli MN, Handzlik J, Liechti ME, Chagraoui A. Arias HR, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 10;136:111217. doi: 10.1016/j.pnpbp.2024.111217. Epub 2024 Dec 9. Prog Neuropsychopharmacol Biol Psychiatry. 2025. PMID: 39662723
116 results