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Discovery of N-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (FD274) as a highly potent PI3K/mTOR dual inhibitor for the treatment of acute myeloid leukemia.
Yang C, Chen Y, Wu T, Gao Y, Liu X, Yang Y, Ling Y, Jia Y, Deng M, Wang J, Zhou Y. Yang C, et al. Among authors: zhou y. Eur J Med Chem. 2023 Oct 5;258:115543. doi: 10.1016/j.ejmech.2023.115543. Epub 2023 Jun 5. Eur J Med Chem. 2023. PMID: 37329712
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