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AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype.
Boon N, Lu X, Andriessen CA, Moustakas I, Buck TM, Freund C, Arendzen CH, Böhringer S, Boon CJF, Mei H, Wijnholds J. Boon N, et al. Among authors: arendzen ch. Stem Cell Reports. 2023 Jun 13;18(6):1388. doi: 10.1016/j.stemcr.2023.05.008. Stem Cell Reports. 2023. PMID: 37315526 Free PMC article. No abstract available.
Generation of two human induced pluripotent stem cell lines, LUMCi020-A and LUMCi021-A, from two patients with Catecholaminergic Polymorphic Ventricular Tachycardia carrying heterozygous mutations in the RYR2 gene.
Meraviglia V, Arendzen CH, Freund C, Atsma DE, Mummery CL, Bellin M. Meraviglia V, et al. Among authors: arendzen ch. Stem Cell Res. 2020 May;45:101764. doi: 10.1016/j.scr.2020.101764. Epub 2020 Apr 8. Stem Cell Res. 2020. PMID: 32315959 Free article.
Generation of human induced pluripotent stem cell line LUMCi027-A and its isogenic gene-corrected line from a patient affected by arrhythmogenic cardiomyopathy and carrying the c.2013delC PKP2 mutation.
Meraviglia V, Arendzen CH, Tok M, Freund C, Maione AS, Sommariva E, Bellin M. Meraviglia V, et al. Among authors: arendzen ch. Stem Cell Res. 2020 Jul;46:101835. doi: 10.1016/j.scr.2020.101835. Epub 2020 May 5. Stem Cell Res. 2020. PMID: 32485643 Free article.
Generation of human induced pluripotent stem cell line EURACi006-A and its isogenic gene-corrected line EURACi006-A-1 from an arrhythmogenic cardiomyopathy patient carrying the c.1643delG PKP2 mutation.
Meraviglia V, Ganesh S, Arendzen CH, Freund C, Sommariva E, Rossini A, Bellin M. Meraviglia V, et al. Among authors: arendzen ch. Stem Cell Res. 2021 Jul;54:102426. doi: 10.1016/j.scr.2021.102426. Epub 2021 Jun 8. Stem Cell Res. 2021. PMID: 34134068 Free article.
CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids.
Buck TM, Quinn PMJ, Pellissier LP, Mulder AA, Jongejan A, Lu X, Boon N, Koot D, Almushattat H, Arendzen CH, Vos RM, Bradley EJ, Freund C, Mikkers HMM, Boon CJF, Moerland PD, Baas F, Koster AJ, Neefjes J, Berlin I, Jost CR, Wijnholds J. Buck TM, et al. Among authors: arendzen ch. Stem Cell Reports. 2023 Sep 12;18(9):1793-1810. doi: 10.1016/j.stemcr.2023.07.001. Epub 2023 Aug 3. Stem Cell Reports. 2023. PMID: 37541258 Free PMC article.
Good Manufacturing Practice-compliant human induced pluripotent stem cells: from bench to putative clinical products.
Novoa JJ, Westra IM, Steeneveld E, Fonseca Neves N, Arendzen CH, Rajaei B, Grundeken E, Yildiz M, van der Valk W, Salvador A, Carlotti F, Dijkers PF, Locher H, van den Berg CW, Raymond KI, Kirkeby A, Mummery CL, Rabelink TJ, Freund C, Meij P, Wieles B. Novoa JJ, et al. Among authors: arendzen ch. Cytotherapy. 2024 Jun;26(6):556-566. doi: 10.1016/j.jcyt.2024.02.021. Epub 2024 Mar 5. Cytotherapy. 2024. PMID: 38483359 Free article.
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