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Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes.
Sun Y, Young MC, Woodward CH, Danon JN, Truong H, Gupta S, Winters TJ, Burslem G, Sgourakis NG. Sun Y, et al. Among authors: young mc. bioRxiv [Preprint]. 2023 Mar 18:2023.03.18.533266. doi: 10.1101/2023.03.18.533266. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2304055120. doi: 10.1073/pnas.2304055120 PMID: 36993702 Free PMC article. Updated. Preprint.
Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion.
Sun Y, Florio TJ, Gupta S, Young MC, Marshall QF, Garfinkle SE, Papadaki GF, Truong HV, Mycek E, Li P, Farrel A, Church NL, Jabar S, Beasley MD, Kiefel BR, Yarmarkovich M, Mallik L, Maris JM, Sgourakis NG. Sun Y, et al. Among authors: young mc. bioRxiv [Preprint]. 2023 May 24:2023.05.24.542108. doi: 10.1101/2023.05.24.542108. bioRxiv. 2023. Update in: Sci Immunol. 2023 Dec;8(90):eadj5792. doi: 10.1126/sciimmunol.adj5792 PMID: 37292750 Free PMC article. Updated. Preprint.
A Chicken Tapasin ortholog can chaperone empty HLA molecules independently of other peptide-loading components.
Papadaki GF, Woodward CH, Young MC, Winters TJ, Burslem GM, Sgourakis NG. Papadaki GF, et al. Among authors: young mc. bioRxiv [Preprint]. 2023 Jun 26:2023.06.23.546255. doi: 10.1101/2023.06.23.546255. bioRxiv. 2023. Update in: J Biol Chem. 2023 Oct;299(10):105136. doi: 10.1016/j.jbc.2023.105136 PMID: 37425753 Free PMC article. Updated. Preprint.
Structural principles of peptide-centric chimeric antigen receptor recognition guide therapeutic expansion.
Sun Y, Florio TJ, Gupta S, Young MC, Marshall QF, Garfinkle SE, Papadaki GF, Truong HV, Mycek E, Li P, Farrel A, Church NL, Jabar S, Beasley MD, Kiefel BR, Yarmarkovich M, Mallik L, Maris JM, Sgourakis NG. Sun Y, et al. Among authors: young mc. Sci Immunol. 2023 Dec;8(90):eadj5792. doi: 10.1126/sciimmunol.adj5792. Epub 2023 Dec 1. Sci Immunol. 2023. PMID: 38039376 Free PMC article.
Regulating IL-2 immune signaling function via a core allosteric structural network.
Woodward CH, Solieva SO, Hwang D, De Paula VS, Fabilane CS, Young MC, Trent T, Teeley EC, Majumdar A, Spangler JB, Bowman GR, Sgourakis NG. Woodward CH, et al. Among authors: young mc. bioRxiv [Preprint]. 2024 Oct 8:2024.10.07.617024. doi: 10.1101/2024.10.07.617024. bioRxiv. 2024. Update in: J Mol Biol. 2024 Dec 9;437(2):168892. doi: 10.1016/j.jmb.2024.168892 PMID: 39416199 Free PMC article. Updated. Preprint.
241 results