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Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.
Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E. Miele C, et al. J Biol Chem. 2003 Nov 28;278(48):47376-87. doi: 10.1074/jbc.M301088200. Epub 2003 Sep 11. J Biol Chem. 2003. PMID: 12970360 Free article.
Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action.
Vigliotta G, Miele C, Santopietro S, Portella G, Perfetti A, Maitan MA, Cassese A, Oriente F, Trencia A, Fiory F, Romano C, Tiveron C, Tatangelo L, Troncone G, Formisano P, Beguinot F. Vigliotta G, et al. Among authors: miele c. Mol Cell Biol. 2004 Jun;24(11):5005-15. doi: 10.1128/MCB.24.11.5005-5015.2004. Mol Cell Biol. 2004. PMID: 15143191 Free PMC article.
Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.
Perfetti A, Oriente F, Iovino S, Alberobello AT, Barbagallo AP, Esposito I, Fiory F, Teperino R, Ungaro P, Miele C, Formisano P, Beguinot F. Perfetti A, et al. Among authors: miele c. J Biol Chem. 2007 Mar 23;282(12):8648-57. doi: 10.1074/jbc.M608359200. Epub 2007 Jan 16. J Biol Chem. 2007. PMID: 17227770 Free article.
196 results