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Page 1
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.
Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M. Soethoudt M, et al. Among authors: baggelaar mp. Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958. Nat Commun. 2017. PMID: 28045021 Free PMC article.
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.
van Esbroeck ACM, Janssen APA, Cognetta AB 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M. van Esbroeck ACM, et al. Among authors: baggelaar mp. Science. 2017 Jun 9;356(6342):1084-1087. doi: 10.1126/science.aaf7497. Science. 2017. PMID: 28596366 Free PMC article.
Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis.
Tomić G, Sheridan C, Refermat AY, Baggelaar MP, Sipthorp J, Sudarshan B, Ocasio CA, Suárez-Bonnet A, Priestnall SL, Herbert E, Tate EW, Downward J. Tomić G, et al. Among authors: baggelaar mp. Cell Rep. 2024 May 28;43(5):114224. doi: 10.1016/j.celrep.2024.114224. Epub 2024 May 11. Cell Rep. 2024. PMID: 38733589 Free article.
A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation.
Ocasio CA, Baggelaar MP, Sipthorp J, Losada de la Lastra A, Tavares M, Volarić J, Soudy C, Storck EM, Houghton JW, Palma-Duran SA, MacRae JI, Tomić G, Carr L, Downward J, Eggert US, Tate EW. Ocasio CA, et al. Among authors: baggelaar mp. Nat Biotechnol. 2024 Oct;42(10):1548-1558. doi: 10.1038/s41587-023-02030-0. Epub 2024 Jan 8. Nat Biotechnol. 2024. PMID: 38191663 Free PMC article.
Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders.
Kaiyrzhanov R, Rad A, Lin SJ, Bertoli-Avella A, Kallemeijn WW, Godwin A, Zaki MS, Huang K, Lau T, Petree C, Efthymiou S, Karimiani EG, Hempel M, Normand EA, Rudnik-Schöneborn S, Schatz UA, Baggelaar MP, Ilyas M, Sultan T, Alvi JR, Ganieva M, Fowler B, Aanicai R, Tayfun GA, Al Saman A, Alswaid A, Amiri N, Asilova N, Shotelersuk V, Yeetong P, Azam M, Babaei M, Monajemi GB, Mohammadi P, Samie S, Banu SH, Pinto Basto J, Kortüm F, Bauer M, Bauer P, Beetz C, Garshasbi M, Issa AH, Eyaid W, Ahmed H, Hashemi N, Hassanpour K, Herman I, Ibrohimov S, Abdul-Majeed BA, Imdad M, Isrofilov M, Kaiyal Q, Khan S, Kirmse B, Koster J, Lourenço CM, Mitani T, Moldovan O, Murphy D, Najafi M, Pehlivan D, Rocha ME, Salpietro V, Schmidts M, Shalata A, Mahroum M, Talbeya JK, Taylor RW, Vazquez D, Vetro A, Waterham HR, Zaman M, Schrader TA, Chung WK, Guerrini R, Lupski JR, Gleeson J, Suri M, Jamshidi Y, Bhatia KP, Vona B, Schrader M, Severino M, Guille M, Tate EW, Varshney GK, Houlden H, Maroofian R. Kaiyrzhanov R, et al. Among authors: baggelaar mp. Brain. 2024 Apr 4;147(4):1436-1456. doi: 10.1093/brain/awad380. Brain. 2024. PMID: 37951597 Free PMC article.
Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles.
van Bergen W, Hevler JF, Wu W, Baggelaar MP, Heck AJR. van Bergen W, et al. Among authors: baggelaar mp. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24. Mol Cell Proteomics. 2023. PMID: 36435334 Free PMC article.
ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction.
Baggelaar MP, den Dulk H, Florea BI, Fazio D, Perruzza D, Bernabò N, Raspa M, Janssen APA, Scavizzi F, Barboni B, Overkleeft HS, Maccarrone M, van der Stelt M. Baggelaar MP, et al. ACS Chem Biol. 2019 Dec 20;14(12):2943. doi: 10.1021/acschembio.9b00824. Epub 2019 Nov 7. ACS Chem Biol. 2019. PMID: 31697462 Free PMC article. No abstract available.
29 results