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Chronic activation of tubulin tyrosination in HCM mice and human iPSC-engineered heart tissues improves heart function.
Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herera-Rivero M, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo MA, Lindner D, Prosser BL, Carrier L. Pietsch N, et al. Among authors: van der velden j. bioRxiv [Preprint]. 2024 Feb 7:2023.05.25.542365. doi: 10.1101/2023.05.25.542365. bioRxiv. 2024. Update in: Circ Res. 2024 Oct 11;135(9):910-932. doi: 10.1161/CIRCRESAHA.124.324387 PMID: 37292763 Free PMC article. Updated. Preprint.
The E3 ubiquitin ligase Asb2β is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation.
Thottakara T, Friedrich FW, Reischmann S, Braumann S, Schlossarek S, Krämer E, Juhr D, Schlüter H, van der Velden J, Münch J, Patten M, Eschenhagen T, Moog-Lutz C, Carrier L. Thottakara T, et al. Among authors: van der velden j. J Mol Cell Cardiol. 2015 Oct;87:214-24. doi: 10.1016/j.yjmcc.2015.08.020. Epub 2015 Sep 3. J Mol Cell Cardiol. 2015. PMID: 26343497
Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice.
Singh SR, Zech ATL, Geertz B, Reischmann-Düsener S, Osinska H, Prondzynski M, Krämer E, Meng Q, Redwood C, van der Velden J, Robbins J, Schlossarek S, Carrier L. Singh SR, et al. Among authors: van der velden j. Circ Heart Fail. 2017 Oct;10(10):e004140. doi: 10.1161/CIRCHEARTFAILURE.117.004140. Circ Heart Fail. 2017. PMID: 29021349 Free PMC article.
The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM.
Piroddi N, Witjas-Paalberends ER, Ferrara C, Ferrantini C, Vitale G, Scellini B, Wijnker PJM, Sequiera V, Dooijes D, Dos Remedios C, Schlossarek S, Leung MC, Messer A, Ward DG, Biggeri A, Tesi C, Carrier L, Redwood CS, Marston SB, van der Velden J, Poggesi C. Piroddi N, et al. Among authors: van der velden j. J Gen Physiol. 2019 Jan 7;151(1):18-29. doi: 10.1085/jgp.201812160. Epub 2018 Dec 21. J Gen Physiol. 2019. PMID: 30578328 Free PMC article.
Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy.
Schuldt M, Pei J, Harakalova M, Dorsch LM, Schlossarek S, Mokry M, Knol JC, Pham TV, Schelfhorst T, Piersma SR, Dos Remedios C, Dalinghaus M, Michels M, Asselbergs FW, Moutin MJ, Carrier L, Jimenez CR, van der Velden J, Kuster DWD. Schuldt M, et al. Among authors: van der velden j. Circ Heart Fail. 2021 Jan;14(1):e007022. doi: 10.1161/CIRCHEARTFAILURE.120.007022. Epub 2021 Jan 12. Circ Heart Fail. 2021. PMID: 33430602 Free PMC article.
EGFR/IGF1R Signaling Modulates Relaxation in Hypertrophic Cardiomyopathy.
Algül S, Schuldt M, Manders E, Jansen V, Schlossarek S, de Goeij-de Haas R, Henneman AA, Piersma SR, Jimenez CR, Michels M, Carrier L, Helmes M, van der Velden J, Kuster DWD. Algül S, et al. Among authors: van der velden j. Circ Res. 2023 Aug 18;133(5):387-399. doi: 10.1161/CIRCRESAHA.122.322133. Epub 2023 Jul 21. Circ Res. 2023. PMID: 37477020 Free article.
Chronic Activation of Tubulin Tyrosination Improves Heart Function.
Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herrera-Rivero M, Siebels B, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo MA, Lindner D, Prosser BL, Carrier L. Pietsch N, et al. Among authors: van der velden j. Circ Res. 2024 Oct 11;135(9):910-932. doi: 10.1161/CIRCRESAHA.124.324387. Epub 2024 Sep 16. Circ Res. 2024. PMID: 39279670 Free PMC article.
631 results