Ziarek JJ - Search Results

1

Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314.

Bumbak F, Bower JB, Zemmer SC, Inoue A, Pons M, Paniagua JC, Yan F, Ford J, Wu H, Robson SA, Bathgate RAD, Scott DJ, Gooley PR, Ziarek JJ. Bumbak F, et al. Among authors: ziarek jj. Nat Commun. 2023 Jun 7;14(1):3328. doi: 10.1038/s41467-023-38894-8. Nat Commun. 2023. PMID: 37286565 Free PMC article.

2

Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine.

Smith EW, Liu Y, Getschman AE, Peterson FC, Ziarek JJ, Li R, Volkman BF, Chen Y. Smith EW, et al. Among authors: ziarek jj. J Med Chem. 2014 Nov 26;57(22):9693-9. doi: 10.1021/jm501194p. Epub 2014 Nov 13. J Med Chem. 2014. PMID: 25356720 Free PMC article.

3

Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide.

Wommack AJ, Ziarek JJ, Tomaras J, Chileveru HR, Zhang Y, Wagner G, Nolan EM. Wommack AJ, et al. Among authors: ziarek jj. J Am Chem Soc. 2014 Oct 1;136(39):13494-7. doi: 10.1021/ja505957w. Epub 2014 Sep 23. J Am Chem Soc. 2014. PMID: 25181039 Free PMC article.

4

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.

Kleist AB, Getschman AE, Ziarek JJ, Nevins AM, Gauthier PA, Chevigné A, Szpakowska M, Volkman BF. Kleist AB, et al. Among authors: ziarek jj. Biochem Pharmacol. 2016 Aug 15;114:53-68. doi: 10.1016/j.bcp.2016.04.007. Epub 2016 Apr 19. Biochem Pharmacol. 2016. PMID: 27106080 Free PMC article. Review.

5

Solution structure of CCL21 and identification of a putative CCR7 binding site.

Love M, Sandberg JL, Ziarek JJ, Gerarden KP, Rode RR, Jensen DR, McCaslin DR, Peterson FC, Veldkamp CT. Love M, et al. Among authors: ziarek jj. Biochemistry. 2012 Jan 24;51(3):733-5. doi: 10.1021/bi201601k. Epub 2012 Jan 17. Biochemistry. 2012. PMID: 22221265 Free PMC article.

6

NMR in the Analysis of Functional Chemokine Interactions and Drug Discovery.

Ziarek JJ, Volkman BF. Ziarek JJ, et al. Drug Discov Today Technol. 2012;9(4):e293-e299. doi: 10.1016/j.ddtec.2012.04.003. Drug Discov Today Technol. 2012. PMID: 23166561 Free PMC article.

7

Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminus.

Ziarek JJ, Veldkamp CT, Zhang F, Murray NJ, Kartz GA, Liang X, Su J, Baker JE, Linhardt RJ, Volkman BF. Ziarek JJ, et al. J Biol Chem. 2013 Jan 4;288(1):737-46. doi: 10.1074/jbc.M112.394064. Epub 2012 Nov 12. J Biol Chem. 2013. PMID: 23148226 Free PMC article.

8

Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4.

Mysinger MM, Weiss DR, Ziarek JJ, Gravel S, Doak AK, Karpiak J, Heveker N, Shoichet BK, Volkman BF. Mysinger MM, et al. Among authors: ziarek jj. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5517-22. doi: 10.1073/pnas.1120431109. Epub 2012 Mar 19. Proc Natl Acad Sci U S A. 2012. PMID: 22431600 Free PMC article.

9

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.

Drury LJ, Ziarek JJ, Gravel S, Veldkamp CT, Takekoshi T, Hwang ST, Heveker N, Volkman BF, Dwinell MB. Drury LJ, et al. Among authors: ziarek jj. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17655-60. doi: 10.1073/pnas.1101133108. Epub 2011 Oct 11. Proc Natl Acad Sci U S A. 2011. PMID: 21990345 Free PMC article.

10

Chemokine cooperativity is caused by competitive glycosaminoglycan binding.

Verkaar F, van Offenbeek J, van der Lee MMC, van Lith LHCJ, Watts AO, Rops ALWMM, Aguilar DC, Ziarek JJ, van der Vlag J, Handel TM, Volkman BF, Proudfoot AEI, Vischer HF, Zaman GJR, Smit MJ. Verkaar F, et al. Among authors: ziarek jj. J Immunol. 2014 Apr 15;192(8):3908-3914. doi: 10.4049/jimmunol.1302159. Epub 2014 Mar 17. J Immunol. 2014. PMID: 24639348 Free PMC article.

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