Gan C - Search Results

1

Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development.

Gan C, Wang J, Wang Y, Martínez-Chávez A, Hillebrand M, de Vries N, Beukers J, Lebre MC, Wagenaar E, Rosing H, Klarenbeek S, Bleijerveld OB, Song JY, Altelaar M, Beijnen JH, Schinkel AH. Gan C, et al. Biomed Pharmacother. 2023 Aug;164:114956. doi: 10.1016/j.biopha.2023.114956. Epub 2023 May 31. Biomed Pharmacother. 2023. PMID: 37267638 Free article.

2

P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) affect brain accumulation and intestinal disposition of encorafenib in mice.

Wang J, Gan C, Sparidans RW, Wagenaar E, van Hoppe S, Beijnen JH, Schinkel AH. Wang J, et al. Among authors: gan c. Pharmacol Res. 2018 Mar;129:414-423. doi: 10.1016/j.phrs.2017.11.006. Epub 2017 Nov 14. Pharmacol Res. 2018. PMID: 29155017

3

P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) limit brain accumulation of the FLT3 inhibitor quizartinib in mice.

Wang J, Gan C, Retmana IA, Sparidans RW, Li W, Lebre MC, Beijnen JH, Schinkel AH. Wang J, et al. Among authors: gan c. Int J Pharm. 2019 Feb 10;556:172-180. doi: 10.1016/j.ijpharm.2018.12.014. Epub 2018 Dec 12. Int J Pharm. 2019. PMID: 30553002

4

Brain accumulation of tivozanib is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein) in mice.

Wang J, Bruin MAC, Gan C, Lebre MC, Rosing H, Beijnen JH, Schinkel AH. Wang J, et al. Among authors: gan c. Int J Pharm. 2020 May 15;581:119277. doi: 10.1016/j.ijpharm.2020.119277. Epub 2020 Mar 28. Int J Pharm. 2020. PMID: 32234426

5

Bioanalytical method for the simultaneous quantification of irinotecan and its active metabolite SN-38 in mouse plasma and tissue homogenates using HPLC-fluorescence.

Martínez-Chávez A, Rosing H, Gan C, Wang Y, Schinkel AH, Beijnen JH. Martínez-Chávez A, et al. Among authors: gan c. J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Jul 15;1149:122177. doi: 10.1016/j.jchromb.2020.122177. Epub 2020 May 19. J Chromatogr B Analyt Technol Biomed Life Sci. 2020. PMID: 32464539 Free article.

6

Human organic anion transporting polypeptide (OATP) 1B3 and mouse OATP1A/1B affect liver accumulation of Ochratoxin A in mice.

Wang J, Gan C, Qi X, Lebre MC, Schinkel AH. Wang J, et al. Among authors: gan c. Toxicol Appl Pharmacol. 2020 Aug 15;401:115072. doi: 10.1016/j.taap.2020.115072. Epub 2020 May 26. Toxicol Appl Pharmacol. 2020. PMID: 32470353

7

P-Glycoprotein (MDR1/ABCB1) Restricts Brain Accumulation of the Novel EGFR Inhibitor EAI045 and Oral Elacridar Coadministration Enhances Its Brain Accumulation and Oral Exposure.

Wang J, Susam MM, Gan C, Sparidans RW, Lebre MC, Beijnen JH, Schinkel AH. Wang J, et al. Among authors: gan c. Pharmaceuticals (Basel). 2022 Sep 8;15(9):1124. doi: 10.3390/ph15091124. Pharmaceuticals (Basel). 2022. PMID: 36145346 Free PMC article.

8

Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism.

Gan C, Wang J, Martínez-Chávez A, Hillebrand M, de Vries N, Beukers J, Wagenaar E, Wang Y, Lebre MC, Rosing H, Klarenbeek S, Ali RB, Pritchard C, Huijbers I, Beijnen JH, Schinkel AH. Gan C, et al. Acta Pharm Sin B. 2023 Feb;13(2):618-631. doi: 10.1016/j.apsb.2022.10.017. Epub 2022 Oct 25. Acta Pharm Sin B. 2023. PMID: 36873183 Free PMC article.

9

Pharmacokinetics of the KRAS^G12C inhibitor adagrasib is limited by CYP3A and ABCB1, and influenced by binding to mouse plasma carboxylesterase 1c.

Loos NHC, Retmana IA, Rijmers J, Wang Y, Gan C, Lebre MC, Sparidans RW, Beijnen JH, Schinkel AH. Loos NHC, et al. Among authors: gan c. Biomed Pharmacother. 2023 Oct;166:115304. doi: 10.1016/j.biopha.2023.115304. Epub 2023 Aug 14. Biomed Pharmacother. 2023. PMID: 37586117 Free article.

10

The "CUPCAKE" technique (coiled underlying pseudoaneurysm contained by a woven endobridge device) for treating intracranial aneurysms with atypical morphology.

Vainauskaite V, Ren Y, Nasra M, Pavlin-Premrl D, Protto S, Siasat P, Khabaza A, Jhamb A, Barras C, Gan C, Motyer R, Smith P, Moore J, Russell J, Slater LA, Chandra R, Brooks M, Chong W, Maingard J, Asadi H. Vainauskaite V, et al. Among authors: gan c. Interv Neuroradiol. 2025 Jan 17:15910199241308602. doi: 10.1177/15910199241308602. Online ahead of print. Interv Neuroradiol. 2025. PMID: 39819149

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