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From concept to delivery: a yeast-expressed recombinant protein-based COVID-19 vaccine technology suitable for global access.
Hotez PJ, Adhikari R, Chen WH, Chen YL, Gillespie P, Islam NY, Keegan B, Tyagi Kundu R, Lee J, Liu Z, Kimata JT, Oezguen N, Pollet J, Poveda C, Razavi K, Ronca SE, Strych U, Thimmiraju SR, Versteeg L, Villar-Mondragon MJ, Wei J, Zhan B, Bottazzi ME. Hotez PJ, et al. Among authors: adhikari r. Expert Rev Vaccines. 2023 Jan-Dec;22(1):495-500. doi: 10.1080/14760584.2023.2217917. Expert Rev Vaccines. 2023. PMID: 37252854 Free article.
SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice.
Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Rivera JA, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME. Pollet J, et al. Among authors: adhikari r. bioRxiv [Preprint]. 2021 Feb 9:2020.11.04.367359. doi: 10.1101/2020.11.04.367359. bioRxiv. 2021. Update in: Hum Vaccin Immunother. 2021 Aug 3;17(8):2356-2366. doi: 10.1080/21645515.2021.1901545 PMID: 33173864 Free PMC article. Updated. Preprint.
Genetic modification to design a stable yeast-expressed recombinant SARS-CoV-2 receptor binding domain as a COVID-19 vaccine candidate.
Chen WH, Wei J, Kundu RT, Adhikari R, Liu Z, Lee J, Versteeg L, Poveda C, Keegan B, Villar MJ, de Araujo Leao AC, Rivera JA, Gillespie PM, Pollet J, Strych U, Zhan B, Hotez PJ, Bottazzi ME. Chen WH, et al. Among authors: adhikari r. Biochim Biophys Acta Gen Subj. 2021 Jun;1865(6):129893. doi: 10.1016/j.bbagen.2021.129893. Epub 2021 Mar 14. Biochim Biophys Acta Gen Subj. 2021. PMID: 33731300 Free PMC article.
SARS‑CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice.
Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Altieri Rivera J, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME. Pollet J, et al. Among authors: adhikari r. Hum Vaccin Immunother. 2021 Aug 3;17(8):2356-2366. doi: 10.1080/21645515.2021.1901545. Epub 2021 Apr 13. Hum Vaccin Immunother. 2021. PMID: 33847226 Free PMC article.
Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern.
Pollet J, Strych U, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, Thimmiraju SR, Lopez B, Gillespie PM, Ronca S, Kimata JT, Reers M, Paradkar V, Hotez P, Bottazzi ME. Pollet J, et al. Among authors: adhikari r. bioRxiv [Preprint]. 2022 Mar 22:2021.07.06.451353. doi: 10.1101/2021.07.06.451353. bioRxiv. 2022. Update in: Vaccine. 2022 Jun 9;40(26):3655-3663. doi: 10.1016/j.vaccine.2022.05.007 PMID: 34268512 Free PMC article. Updated. Preprint.
Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi.
Versteeg L, Adhikari R, Poveda C, Villar-Mondragon MJ, Jones KM, Hotez PJ, Bottazzi ME, Tijhaar E, Pollet J. Versteeg L, et al. Among authors: adhikari r. PLoS Negl Trop Dis. 2021 Sep 3;15(9):e0009689. doi: 10.1371/journal.pntd.0009689. eCollection 2021 Sep. PLoS Negl Trop Dis. 2021. PMID: 34478444 Free PMC article.
Yeast-expressed recombinant SARS-CoV-2 receptor binding domain RBD203-N1 as a COVID-19 protein vaccine candidate.
Chen WH, Pollet J, Strych U, Lee J, Liu Z, Kundu RT, Versteeg L, Villar MJ, Adhikari R, Wei J, Poveda C, Keegan B, Bailey AO, Chen YL, Gillespie PM, Kimata JT, Zhan B, Hotez PJ, Bottazzi ME. Chen WH, et al. Among authors: adhikari r. Protein Expr Purif. 2022 Feb;190:106003. doi: 10.1016/j.pep.2021.106003. Epub 2021 Oct 21. Protein Expr Purif. 2022. PMID: 34688919 Free PMC article.
Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern.
Pollet J, Strych U, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Jose Villar M, Rani Thimmiraju S, Lopez B, Gillespie PM, Ronca S, Kimata JT, Reers M, Paradkar V, Hotez PJ, Elena Bottazzi M. Pollet J, et al. Among authors: adhikari r. Vaccine. 2022 Jun 9;40(26):3655-3663. doi: 10.1016/j.vaccine.2022.05.007. Epub 2022 May 8. Vaccine. 2022. PMID: 35568591 Free PMC article.
Heterologous mRNA-protein vaccination with Tc24 induces a robust cellular immune response against Trypanosoma cruzi, characterized by an increased level of polyfunctional CD8+ T-cells.
Poveda C, Leão AC, Mancino C, Taraballi F, Chen YL, Adhikari R, Villar MJ, Kundu R, Nguyen DM, Versteeg L, Strych U, Hotez PJ, Bottazzi ME, Pollet J, Jones KM. Poveda C, et al. Among authors: adhikari r. Curr Res Immunol. 2023 Jul 20;4:100066. doi: 10.1016/j.crimmu.2023.100066. eCollection 2023. Curr Res Immunol. 2023. PMID: 37534309 Free PMC article.
670 results