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FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer's disease.
Novak P, Schmidt R, Kontsekova E, Kovacech B, Smolek T, Katina S, Fialova L, Prcina M, Parrak V, Dal-Bianco P, Brunner M, Staffen W, Rainer M, Ondrus M, Ropele S, Smisek M, Sivak R, Zilka N, Winblad B, Novak M. Novak P, et al. Among authors: zilka n. Alzheimers Res Ther. 2018 Oct 24;10(1):108. doi: 10.1186/s13195-018-0436-1. Alzheimers Res Ther. 2018. PMID: 30355322 Free PMC article. Clinical Trial.
Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models.
McMurray L, Macdonald JA, Ramakrishnan NK, Zhao Y, Williamson DW, Tietz O, Zhou X, Kealey S, Fagan SG, Smolek T, Cubinkova V, Žilka N, Spillantini MG, Tolkovsky AM, Goedert M, Aigbirhio FI. McMurray L, et al. Among authors: zilka n. ACS Chem Neurosci. 2021 Jun 2;12(11):1885-1893. doi: 10.1021/acschemneuro.0c00790. Epub 2021 Mar 10. ACS Chem Neurosci. 2021. PMID: 33689290 Free PMC article.
Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans.
Weisová P, Cehlár O, Škrabana R, Žilková M, Filipčík P, Kováčech B, Prčina M, Wojčiaková Ľ, Fialová Ľ, Smolek T, Kontseková E, Žilka N, Novák M. Weisová P, et al. Among authors: zilka n. Acta Neuropathol Commun. 2019 Aug 7;7(1):129. doi: 10.1186/s40478-019-0770-y. Acta Neuropathol Commun. 2019. PMID: 31391090 Free PMC article.
Evaluation of a novel immunoassay to detect p-tau Thr217 in the CSF to distinguish Alzheimer disease from other dementias.
Hanes J, Kovac A, Kvartsberg H, Kontsekova E, Fialova L, Katina S, Kovacech B, Stevens E, Hort J, Vyhnalek M, Boonkamp L, Novak M, Zetterberg H, Hansson O, Scheltens P, Blennow K, Teunissen CE, Zilka N. Hanes J, et al. Among authors: zilka n. Neurology. 2020 Dec 1;95(22):e3026-e3035. doi: 10.1212/WNL.0000000000010814. Epub 2020 Sep 24. Neurology. 2020. PMID: 32973122 Free PMC article.
91 results