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Page 1
Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants.
Tamura T, Ito J, Uriu K, Zahradnik J, Kida I, Anraku Y, Nasser H, Shofa M, Oda Y, Lytras S, Nao N, Itakura Y, Deguchi S, Suzuki R, Wang L, Begum MM, Kita S, Yajima H, Sasaki J, Sasaki-Tabata K, Shimizu R, Tsuda M, Kosugi Y, Fujita S, Pan L, Sauter D, Yoshimatsu K, Suzuki S, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Yamamoto Y, Nagamoto T, Schreiber G, Maenaka K; Genotype to Phenotype Japan (G2P-Japan) Consortium; Hashiguchi T, Ikeda T, Fukuhara T, Saito A, Tanaka S, Matsuno K, Takayama K, Sato K. Tamura T, et al. Among authors: anraku y. Nat Commun. 2023 May 16;14(1):2800. doi: 10.1038/s41467-023-38435-3. Nat Commun. 2023. PMID: 37193706 Free PMC article.
A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site.
Onodera T, Kita S, Adachi Y, Moriyama S, Sato A, Nomura T, Sakakibara S, Inoue T, Tadokoro T, Anraku Y, Yumoto K, Tian C, Fukuhara H, Sasaki M, Orba Y, Shiwa N, Iwata N, Nagata N, Suzuki T, Sasaki J, Sekizuka T, Tonouchi K, Sun L, Fukushi S, Satofuka H, Kazuki Y, Oshimura M, Kurosaki T, Kuroda M, Matsuura Y, Suzuki T, Sawa H, Hashiguchi T, Maenaka K, Takahashi Y. Onodera T, et al. Among authors: anraku y. Immunity. 2021 Oct 12;54(10):2385-2398.e10. doi: 10.1016/j.immuni.2021.08.025. Epub 2021 Aug 24. Immunity. 2021. PMID: 34508662 Free PMC article.
Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants.
Ozawa T, Tani H, Anraku Y, Kita S, Igarashi E, Saga Y, Inasaki N, Kawasuji H, Yamada H, Sasaki SI, Somekawa M, Sasaki J, Hayakawa Y, Yamamoto Y, Morinaga Y, Kurosawa N, Isobe M, Fukuhara H, Maenaka K, Hashiguchi T, Kishi H, Kitajima I, Saito S, Niimi H. Ozawa T, et al. Among authors: anraku y. MAbs. 2022 Jan-Dec;14(1):2072455. doi: 10.1080/19420862.2022.2072455. MAbs. 2022. PMID: 35543180 Free PMC article.
Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.
Heo Y, Ishimoto N, Jeon YE, Yun JH, Ohki M, Anraku Y, Sasaki M, Kita S, Fukuhara H, Ikuta T, Kawakami K, Inoue A, Maenaka K, Tame JRH, Lee W, Park SY. Heo Y, et al. Among authors: anraku y. PLoS Biol. 2022 Aug 1;20(8):e3001714. doi: 10.1371/journal.pbio.3001714. eCollection 2022 Aug. PLoS Biol. 2022. PMID: 35913979 Free PMC article.
Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant.
Saito A, Tamura T, Zahradnik J, Deguchi S, Tabata K, Anraku Y, Kimura I, Ito J, Yamasoba D, Nasser H, Toyoda M, Nagata K, Uriu K, Kosugi Y, Fujita S, Shofa M, Monira Begum M, Shimizu R, Oda Y, Suzuki R, Ito H, Nao N, Wang L, Tsuda M, Yoshimatsu K, Kuramochi J, Kita S, Sasaki-Tabata K, Fukuhara H, Maenaka K, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Ueno T, Schreiber G, Takaori-Kondo A; Genotype to Phenotype Japan (G2P-Japan) Consortium; Shirakawa K, Sawa H, Irie T, Hashiguchi T, Takayama K, Matsuno K, Tanaka S, Ikeda T, Fukuhara T, Sato K. Saito A, et al. Among authors: anraku y. Cell Host Microbe. 2022 Nov 9;30(11):1540-1555.e15. doi: 10.1016/j.chom.2022.10.003. Epub 2022 Oct 18. Cell Host Microbe. 2022. PMID: 36272413 Free PMC article.
Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants.
Moriyama S, Anraku Y, Taminishi S, Adachi Y, Kuroda D, Kita S, Higuchi Y, Kirita Y, Kotaki R, Tonouchi K, Yumoto K, Suzuki T, Someya T, Fukuhara H, Kuroda Y, Yamamoto T, Onodera T, Fukushi S, Maeda K, Nakamura-Uchiyama F, Hashiguchi T, Hoshino A, Maenaka K, Takahashi Y. Moriyama S, et al. Among authors: anraku y. Nat Commun. 2023 Jul 14;14(1):4198. doi: 10.1038/s41467-023-39890-8. Nat Commun. 2023. PMID: 37452031 Free PMC article.
2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses.
Uemura K, Nobori H, Sato A, Toba S, Kusakabe S, Sasaki M, Tabata K, Matsuno K, Maeda N, Ito S, Tanaka M, Anraku Y, Kita S, Ishii M, Kanamitsu K, Orba Y, Matsuura Y, Hall WW, Sawa H, Kida H, Matsuda A, Maenaka K. Uemura K, et al. Among authors: anraku y. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2304139120. doi: 10.1073/pnas.2304139120. Epub 2023 Oct 13. Proc Natl Acad Sci U S A. 2023. PMID: 37831739 Free PMC article.
Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA.1.
Ozawa T, Ikeda Y, Chen L, Suzuki R, Hoshino A, Noguchi A, Kita S, Anraku Y, Igarashi E, Saga Y, Inasaki N, Taminishi S, Sasaki J, Kirita Y, Fukuhara H, Maenaka K, Hashiguchi T, Fukuhara T, Hirabayashi K, Tani H, Kishi H, Niimi H. Ozawa T, et al. Among authors: anraku y. Structure. 2024 Mar 7;32(3):263-272.e7. doi: 10.1016/j.str.2023.12.013. Epub 2024 Jan 15. Structure. 2024. PMID: 38228146
Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant.
Tamura T, Irie T, Deguchi S, Yajima H, Tsuda M, Nasser H, Mizuma K, Plianchaisuk A, Suzuki S, Uriu K, Begum MM, Shimizu R, Jonathan M, Suzuki R, Kondo T, Ito H, Kamiyama A, Yoshimatsu K, Shofa M, Hashimoto R, Anraku Y, Kimura KT, Kita S, Sasaki J, Sasaki-Tabata K, Maenaka K, Nao N, Wang L, Oda Y; Genotype to Phenotype Japan (G2P-Japan) Consortium; Ikeda T, Saito A, Matsuno K, Ito J, Tanaka S, Sato K, Hashiguchi T, Takayama K, Fukuhara T. Tamura T, et al. Among authors: anraku y. Nat Commun. 2024 Feb 8;15(1):1176. doi: 10.1038/s41467-024-45274-3. Nat Commun. 2024. PMID: 38332154 Free PMC article.
Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant.
Tsujino S, Deguchi S, Nomai T, Padilla-Blanco M, Plianchaisuk A, Wang L, Begum MM, Uriu K, Mizuma K, Nao N, Kojima I, Tsubo T, Li J, Matsumura Y, Nagao M, Oda Y, Tsuda M, Anraku Y, Kita S, Yajima H, Sasaki-Tabata K, Guo Z, Hinay AA Jr, Yoshimatsu K, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Nasser H, Jonathan M, Putri O, Kim Y, Chen L, Suzuki R, Tamura T, Maenaka K, Irie T, Matsuno K, Tanaka S, Ito J, Ikeda T, Takayama K, Zahradnik J, Hashiguchi T, Fukuhara T, Sato K; Genotype to Phenotype Japan (G2P‐Japan) Consortium. Tsujino S, et al. Among authors: anraku y. Microbiol Immunol. 2024 Sep;68(9):305-330. doi: 10.1111/1348-0421.13165. Epub 2024 Jul 4. Microbiol Immunol. 2024. PMID: 38961765
335 results