Wootten D - Search Results

1

Glycosylation Improves the Proteolytic Stability of Exenatide.

Chandrashekar C, Nishiuchi Y, White BF, Arsenakis Y, Lin F, McNeill SM, Zhao P, van Dun S, Koijen A, Kajihara Y, Wootten D, van den Bos LJ, Wade JD, Hossain MA. Chandrashekar C, et al. Among authors: wootten d. Bioconjug Chem. 2023 Jun 21;34(6):1014-1018. doi: 10.1021/acs.bioconjchem.3c00120. Epub 2023 May 16. Bioconjug Chem. 2023. PMID: 37192432

2

Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47)hCT((a)) function.

Qi T, Dong M, Watkins HA, Wootten D, Miller LJ, Hay DL. Qi T, et al. Among authors: wootten d. Br J Pharmacol. 2013 Feb;168(3):644-57. doi: 10.1111/j.1476-5381.2012.02197.x. Br J Pharmacol. 2013. PMID: 22946511 Free PMC article.

3

Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.

Willard FS, Wootten D, Showalter AD, Savage EE, Ficorilli J, Farb TB, Bokvist K, Alsina-Fernandez J, Furness SG, Christopoulos A, Sexton PM, Sloop KW. Willard FS, et al. Among authors: wootten d. Mol Pharmacol. 2012 Dec;82(6):1066-73. doi: 10.1124/mol.112.080432. Epub 2012 Aug 28. Mol Pharmacol. 2012. PMID: 22930710

4

Mechanisms of signalling and biased agonism in G protein-coupled receptors.

Wootten D, Christopoulos A, Marti-Solano M, Babu MM, Sexton PM. Wootten D, et al. Nat Rev Mol Cell Biol. 2018 Oct;19(10):638-653. doi: 10.1038/s41580-018-0049-3. Nat Rev Mol Cell Biol. 2018. PMID: 30104700 Review.

5

Diverse functional motifs within the three intracellular loops of the CGRP1 receptor.

Conner AC, Simms J, Conner MT, Wootten DL, Wheatley M, Poyner DR. Conner AC, et al. Biochemistry. 2006 Oct 31;45(43):12976-85. doi: 10.1021/bi0615801. Biochemistry. 2006. PMID: 17059214

6

Receptor activity modifying proteins (RAMPs) interact with the VPAC2 receptor and CRF1 receptors and modulate their function.

Wootten D, Lindmark H, Kadmiel M, Willcockson H, Caron KM, Barwell J, Drmota T, Poyner DR. Wootten D, et al. Br J Pharmacol. 2013 Feb;168(4):822-34. doi: 10.1111/j.1476-5381.2012.02202.x. Br J Pharmacol. 2013. PMID: 22946657 Free PMC article.

7

The Molecular Control of Calcitonin Receptor Signaling.

Dal Maso E, Glukhova A, Zhu Y, Garcia-Nafria J, Tate CG, Atanasio S, Reynolds CA, Ramírez-Aportela E, Carazo JM, Hick CA, Furness SGB, Hay DL, Liang YL, Miller LJ, Christopoulos A, Wang MW, Wootten D, Sexton PM. Dal Maso E, et al. Among authors: wootten d. ACS Pharmacol Transl Sci. 2019 Jan 11;2(1):31-51. doi: 10.1021/acsptsci.8b00056. eCollection 2019 Feb 8. ACS Pharmacol Transl Sci. 2019. PMID: 32219215 Free PMC article.

8

Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.

Conner M, Hawtin SR, Simms J, Wootten D, Lawson Z, Conner AC, Parslow RA, Wheatley M. Conner M, et al. Among authors: wootten d. J Biol Chem. 2007 Jun 15;282(24):17405-12. doi: 10.1074/jbc.M702151200. Epub 2007 Apr 2. J Biol Chem. 2007. PMID: 17403667 Free article.

9

Lifting the lid on GPCRs: the role of extracellular loops.

Wheatley M, Wootten D, Conner MT, Simms J, Kendrick R, Logan RT, Poyner DR, Barwell J. Wheatley M, et al. Among authors: wootten d. Br J Pharmacol. 2012 Mar;165(6):1688-1703. doi: 10.1111/j.1476-5381.2011.01629.x. Br J Pharmacol. 2012. PMID: 21864311 Free PMC article. Review.

10

Agonist-specific requirement for a glutamate in transmembrane helix 1 of the oxytocin receptor.

Wootten DL, Simms J, Massoura AJ, Trim JE, Wheatley M. Wootten DL, et al. Mol Cell Endocrinol. 2011 Feb 10;333(1):20-7. doi: 10.1016/j.mce.2010.11.029. Epub 2010 Dec 3. Mol Cell Endocrinol. 2011. PMID: 21130837

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