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P2X7 receptor contributes to long-term neuroinflammation and cognitive impairment in sepsis-surviving mice.
Alves VS, da Silva JP, Rodrigues FC, Araújo SMB, Gouvêa AL, Leite-Aguiar R, Santos SACS, da Silva MSP, Ferreira FS, Marques EP, Dos Passos BABR, Maron-Gutierrez T, Kurtenbach E, da Costa R, Figueiredo CP, Wyse ATS, Coutinho-Silva R, Savio LEB. Alves VS, et al. Among authors: figueiredo cp. Front Pharmacol. 2023 Apr 21;14:1179723. doi: 10.3389/fphar.2023.1179723. eCollection 2023. Front Pharmacol. 2023. PMID: 37153798 Free PMC article.
Innate immune memory mediates increased susceptibility to Alzheimer's disease-like pathology in sepsis surviving mice.
De Sousa VL, Araújo SB, Antonio LM, Silva-Queiroz M, Colodeti LC, Soares C, Barros-Aragão F, Mota-Araujo HP, Alves VS, Coutinho-Silva R, Savio LEB, Ferreira ST, Da Costa R, Clarke JR, Figueiredo CP. De Sousa VL, et al. Among authors: figueiredo cp. Brain Behav Immun. 2021 Jul;95:287-298. doi: 10.1016/j.bbi.2021.04.001. Epub 2021 Apr 8. Brain Behav Immun. 2021. PMID: 33838250
Skeletal Muscle Is an Early Site of Zika Virus Replication and Injury, Which Impairs Myogenesis.
Gavino-Leopoldino D, Figueiredo CM, da Silva MOL, Barcellos LG, Neris RLS, Pinto LDM, Araújo SMB, Ladislau L, Benjamim CF, Da Poian AT, Clarke JR, Figueiredo CP, Assunção-Miranda I. Gavino-Leopoldino D, et al. Among authors: figueiredo cm, figueiredo cp. J Virol. 2021 Oct 27;95(22):e0090421. doi: 10.1128/JVI.00904-21. Epub 2021 Sep 1. J Virol. 2021. PMID: 34468171 Free PMC article.
SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice.
Fontes-Dantas FL, Fernandes GG, Gutman EG, De Lima EV, Antonio LS, Hammerle MB, Mota-Araujo HP, Colodeti LC, Araújo SMB, Froz GM, da Silva TN, Duarte LA, Salvio AL, Pires KL, Leon LAA, Vasconcelos CCF, Romão L, Savio LEB, Silva JL, da Costa R, Clarke JR, Da Poian AT, Alves-Leon SV, Passos GF, Figueiredo CP. Fontes-Dantas FL, et al. Among authors: figueiredo cp. Cell Rep. 2023 Mar 28;42(3):112189. doi: 10.1016/j.celrep.2023.112189. Epub 2023 Feb 17. Cell Rep. 2023. PMID: 36857178 Free PMC article.
SARS-CoV-2 Spike protein alters microglial purinergic signaling.
Alves VS, Santos SACS, Leite-Aguiar R, Paiva-Pereira E, Dos Reis RR, Calazans ML, Fernandes GG, Antônio LS, de Lima EV, Kurtenbach E, Silva JL, Fontes-Dantas FL, Passos GF, Figueiredo CP, Coutinho-Silva R, Savio LEB. Alves VS, et al. Among authors: figueiredo cp. Front Immunol. 2023 Apr 11;14:1158460. doi: 10.3389/fimmu.2023.1158460. eCollection 2023. Front Immunol. 2023. PMID: 37114062 Free PMC article.
Mitotherapy prevents peripheral neuropathy induced by oxaliplatin in mice.
Maia JRLCB, Machado LKA, Fernandes GG, Vitorino LC, Antônio LS, Araújo SMB, Colodeti LC, Fontes-Dantas FL, Zeidler JD, Saraiva GN, Da Poian AT, Figueiredo CP, Passos GF, da Costa R. Maia JRLCB, et al. Among authors: figueiredo cp. Neuropharmacology. 2024 Mar 1;245:109828. doi: 10.1016/j.neuropharm.2023.109828. Epub 2023 Dec 27. Neuropharmacology. 2024. PMID: 38158014
Abatacept inhibits Th17 differentiation and mitigates α-synuclein-induced dopaminergic dysfunction in mice.
Clarke JR, Bacelar TS, Fernandes GG, Silva RCD, Antonio LS, Queiroz M, de Souza RV, Valadão LF, Ribeiro GS, De Lima EV, Colodeti LC, Mangeth LC, Wiecikowski A, da Silva TN, Paula-Neto HA, da Costa R, Cordeiro Y, Passos GF, Figueiredo CP. Clarke JR, et al. Among authors: figueiredo cp. Mol Psychiatry. 2025 Feb;30(2):547-555. doi: 10.1038/s41380-024-02618-1. Epub 2024 Aug 16. Mol Psychiatry. 2025. PMID: 39152331
Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β(1-40) administration in mice: evidence for dissociation between cognitive deficits and neuronal damage.
Piermartiri TC, Figueiredo CP, Rial D, Duarte FS, Bezerra SC, Mancini G, de Bem AF, Prediger RD, Tasca CI. Piermartiri TC, et al. Among authors: figueiredo cp. Exp Neurol. 2010 Dec;226(2):274-84. doi: 10.1016/j.expneurol.2010.08.030. Epub 2010 Sep 15. Exp Neurol. 2010. PMID: 20816828 Free article.
Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.
Neves FS, Marques PT, Barros-Aragão F, Nunes JB, Venancio AM, Cozachenco D, Frozza RL, Passos GF, Costa R, de Oliveira J, Engel DF, De Bem AF, Benjamim CF, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP. Neves FS, et al. Among authors: figueiredo cp. Mol Neurobiol. 2018 Jan;55(1):435-444. doi: 10.1007/s12035-016-0307-3. Epub 2016 Dec 13. Mol Neurobiol. 2018. PMID: 27966074
152 results