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Scavenging dicarbonyls with 5'-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance.
Huang J, Tao H, Yancey PG, Leuthner Z, May-Zhang LS, Jung JY, Zhang Y, Ding L, Amarnath V, Liu D, Collins S, Davies SS, Linton MF. Huang J, et al. Among authors: leuthner z. Mol Metab. 2023 Jan;67:101651. doi: 10.1016/j.molmet.2022.101651. Epub 2022 Dec 5. Mol Metab. 2023. PMID: 36481344 Free PMC article.
The FoxOs are in the ApoM house.
Linton MF, Yancey PG, Leuthner ZM, Brown JD. Linton MF, et al. Among authors: leuthner zm. J Clin Invest. 2022 Apr 1;132(7):e158471. doi: 10.1172/JCI158471. J Clin Invest. 2022. PMID: 35362476 Free PMC article.