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IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.
Andlovic B, Heilmann G, Ninck S, Andrei SA, Centorrino F, Higuchi Y, Kato N, Brunsveld L, Arkin M, Menninger S, Choidas A, Wolf A, Klebl B, Kaschani F, Kaiser M, Eickhoff J, Ottmann C. Andlovic B, et al. Among authors: andrei sa. Cell Chem Biol. 2023 Jun 15;30(6):573-590.e6. doi: 10.1016/j.chembiol.2023.04.005. Epub 2023 May 1. Cell Chem Biol. 2023. PMID: 37130519 Free article.
Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers.
Sijbesma E, Hallenbeck KK, Andrei SA, Rust RR, Adriaans JMC, Brunsveld L, Arkin MR, Ottmann C. Sijbesma E, et al. Among authors: andrei sa. ACS Med Chem Lett. 2021 May 10;12(6):976-982. doi: 10.1021/acsmedchemlett.1c00088. eCollection 2021 Jun 10. ACS Med Chem Lett. 2021. PMID: 34136078 Free PMC article.
Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.
Doveston RG, Kuusk A, Andrei SA, Leysen S, Cao Q, Castaldi MP, Hendricks A, Brunsveld L, Chen H, Boyd H, Ottmann C. Doveston RG, et al. Among authors: andrei sa. FEBS Lett. 2017 Aug;591(16):2449-2457. doi: 10.1002/1873-3468.12723. Epub 2017 Aug 6. FEBS Lett. 2017. PMID: 28640363 Free article.
Stabilization of protein-protein interactions in drug discovery.
Andrei SA, Sijbesma E, Hann M, Davis J, O'Mahony G, Perry MWD, Karawajczyk A, Eickhoff J, Brunsveld L, Doveston RG, Milroy LG, Ottmann C. Andrei SA, et al. Expert Opin Drug Discov. 2017 Sep;12(9):925-940. doi: 10.1080/17460441.2017.1346608. Epub 2017 Jul 11. Expert Opin Drug Discov. 2017. PMID: 28695752 Free article. Review.
Designed Spiroketal Protein Modulation.
Scheepstra M, Andrei SA, Unver MY, Hirsch AKH, Leysen S, Ottmann C, Brunsveld L, Milroy LG. Scheepstra M, et al. Among authors: andrei sa. Angew Chem Int Ed Engl. 2017 May 8;56(20):5480-5484. doi: 10.1002/anie.201612504. Epub 2017 Apr 13. Angew Chem Int Ed Engl. 2017. PMID: 28407400 Free PMC article.
20 results