Felber JG - Search Results

1

Cyclic Dichalcogenides Extend the Reach of Bioreductive Prodrugs to Harness Thiol/Disulfide Oxidoreductases: Applications to seco-Duocarmycins Targeting the Thioredoxin System.

Felber JG, Kitowski A, Zeisel L, Maier MS, Heise C, Thorn-Seshold J, Thorn-Seshold O. Felber JG, et al. ACS Cent Sci. 2023 Mar 28;9(4):763-776. doi: 10.1021/acscentsci.2c01465. eCollection 2023 Apr 26. ACS Cent Sci. 2023. PMID: 37122469 Free PMC article.

2

Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif.

Felber JG, Zeisel L, Poczka L, Scholzen K, Busker S, Maier MS, Theisen U, Brandstädter C, Becker K, Arnér ESJ, Thorn-Seshold J, Thorn-Seshold O. Felber JG, et al. J Am Chem Soc. 2021 Jun 16;143(23):8791-8803. doi: 10.1021/jacs.1c03234. Epub 2021 Jun 1. J Am Chem Soc. 2021. PMID: 34061528 Free article.

3

Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically.

Felber JG, Poczka L, Scholzen KC, Zeisel L, Maier MS, Busker S, Theisen U, Brandstädter C, Becker K, Arnér ESJ, Thorn-Seshold J, Thorn-Seshold O. Felber JG, et al. Nat Commun. 2022 Apr 1;13(1):1754. doi: 10.1038/s41467-022-29136-4. Nat Commun. 2022. PMID: 35365603 Free PMC article.

4

Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe.

Zeisel L, Felber JG, Scholzen KC, Poczka L, Cheff D, Maier MS, Cheng Q, Shen M, Hall MD, Arnér ESJ, Thorn-Seshold J, Thorn-Seshold O. Zeisel L, et al. Among authors: felber jg. Chem. 2022 May 12;8(5):1493-1517. doi: 10.1016/j.chempr.2022.03.010. Epub 2022 Apr 14. Chem. 2022. PMID: 35936029 Free PMC article.

5

40 Years of Duocarmycins: A Graphical Structure/Function Review of Their Chemical Evolution, from SAR to Prodrugs and ADCs.

Felber JG, Thorn-Seshold O. Felber JG, et al. JACS Au. 2022 Nov 15;2(12):2636-2644. doi: 10.1021/jacsau.2c00448. eCollection 2022 Dec 26. JACS Au. 2022. PMID: 36590260 Free PMC article. Review.

6

Correction to "40 Years of Duocarmycins: A Graphical Structure/Function Review of Their Chemical Evolution, from SAR to Prodrugs and ADCs".

Felber JG, Thorn-Seshold O. Felber JG, et al. JACS Au. 2023 Apr 19;3(5):1534. doi: 10.1021/jacsau.3c00137. eCollection 2023 May 22. JACS Au. 2023. PMID: 37234106 Free PMC article.

7

Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology.

Zeisel L, Felber JG, Scholzen KC, Schmitt C, Wiegand AJ, Komissarov L, Arnér ESJ, Thorn-Seshold O. Zeisel L, et al. Among authors: felber jg. J Am Chem Soc. 2024 Feb 28;146(8):5204-5214. doi: 10.1021/jacs.3c11153. Epub 2024 Feb 15. J Am Chem Soc. 2024. PMID: 38358897

8

Aminomethylation/hydrogenolysis as an alternative to direct methylation of metalated isoquinolines - a novel total synthesis of the alkaloid 7-hydroxy-6-methoxy-1-methylisoquinoline.

Melzer BC, Felber JG, Bracher F. Melzer BC, et al. Among authors: felber jg. Beilstein J Org Chem. 2018 Jan 11;14:130-134. doi: 10.3762/bjoc.14.8. eCollection 2018. Beilstein J Org Chem. 2018. PMID: 29441136 Free PMC article.

9

Chemical Proteomic Discovery of Isotype-Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2.

Tao Y, Felber JG, Zou Z, Njomen E, Remsberg JR, Ogasawara D, Ye C, Melillo B, Schreiber SL, He C, Remillard D, Cravatt BF. Tao Y, et al. Among authors: felber jg. Angew Chem Int Ed Engl. 2023 Dec 18;62(51):e202311924. doi: 10.1002/anie.202311924. Epub 2023 Nov 14. Angew Chem Int Ed Engl. 2023. PMID: 37909922 Free PMC article.

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