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Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice.
Hedges CP, Shetty B, Broome SC, MacRae C, Koutsifeli P, Buckels EJ, MacIndoe C, Boix J, Tsiloulis T, Matthews BG, Sinha S, Arendse M, Jaiswal JK, Mellor KM, Hickey AJR, Shepherd PR, Merry TL. Hedges CP, et al. Among authors: shepherd pr. Nat Aging. 2023 Feb;3(2):162-172. doi: 10.1038/s43587-022-00349-y. Epub 2023 Jan 23. Nat Aging. 2023. PMID: 37118113
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.
Gong GQ, Masson GR, Lee WJ, Dickson JMJ, Kendall JD, Rathinaswamy MK, Buchanan CM, Middleditch M, Owen BM, Spicer JA, Rewcastle GW, Denny WA, Burke JE, Shepherd PR, Williams RL, Flanagan JU. Gong GQ, et al. Among authors: shepherd pr. Biochem J. 2024 Dec 4;481(23):1787-1802. doi: 10.1042/BCJ20240479. Biochem J. 2024. PMID: 39485310 Free PMC article.
The population-specific Thr44Met OCT3 coding variant affects metformin pharmacokinetics with subsequent effects on insulin sensitivity in C57Bl/6J mice.
Wang Q, Leask MP, Lee K, Jaiswal J, Kallingappa P, Dissanayake W, Puli'uvea C, O'Sullivan C, Watson H, Wilcox P, Murphy R, Merry TL, Shepherd PR. Wang Q, et al. Among authors: shepherd pr. Diabetologia. 2024 Oct 18. doi: 10.1007/s00125-024-06287-1. Online ahead of print. Diabetologia. 2024. PMID: 39422716
A role for β-catenin in diet-induced skeletal muscle insulin resistance.
Masson SWC, Dissanayake WC, Broome SC, Hedges CP, Peeters WM, Gram M, Rowlands DS, Shepherd PR, Merry TL. Masson SWC, et al. Among authors: shepherd pr. Physiol Rep. 2023 Feb;11(4):e15536. doi: 10.14814/phy2.15536. Physiol Rep. 2023. PMID: 36807886 Free PMC article.
Stratified glucose-lowering response to vildagliptin and pioglitazone by obesity and hypertriglyceridemia in a randomized crossover trial.
Brandon R, Jiang Y, Yeu RQ, Tweedie-Cullen R, Smallman K, Doherty G, Macaskill-Smith KA, Doran RJ, Clark P, Moffitt A, Merry T, Nehren N, King F, Hindmarsh JH, Leask MP, Merriman TR, Orr-Walker B, Shepherd PR, Paul R, Murphy R. Brandon R, et al. Among authors: shepherd pr. Front Endocrinol (Lausanne). 2023 Jan 9;13:1091421. doi: 10.3389/fendo.2022.1091421. eCollection 2022. Front Endocrinol (Lausanne). 2023. PMID: 36699039 Free PMC article. Clinical Trial.
173 results