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Non-specificity as the sticky problem in therapeutic antibody development.
Ausserwöger H, Schneider MM, Herling TW, Arosio P, Invernizzi G, Knowles TPJ, Lorenzen N. Ausserwöger H, et al. Among authors: arosio p. Nat Rev Chem. 2022 Dec;6(12):844-861. doi: 10.1038/s41570-022-00438-x. Epub 2022 Nov 14. Nat Rev Chem. 2022. PMID: 37117703 Review.
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.
Lorenzen N, Nielsen SB, Buell AK, Kaspersen JD, Arosio P, Vad BS, Paslawski W, Christiansen G, Valnickova-Hansen Z, Andreasen M, Enghild JJ, Pedersen JS, Dobson CM, Knowles TP, Otzen DE. Lorenzen N, et al. Among authors: arosio p. J Am Chem Soc. 2014 Mar 12;136(10):3859-68. doi: 10.1021/ja411577t. Epub 2014 Feb 28. J Am Chem Soc. 2014. PMID: 24527756
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.
Cohen SIA, Arosio P, Presto J, Kurudenkandy FR, Biverstal H, Dolfe L, Dunning C, Yang X, Frohm B, Vendruscolo M, Johansson J, Dobson CM, Fisahn A, Knowles TPJ, Linse S. Cohen SIA, et al. Among authors: arosio p. Nat Struct Mol Biol. 2015 Mar;22(3):207-213. doi: 10.1038/nsmb.2971. Epub 2015 Feb 16. Nat Struct Mol Biol. 2015. PMID: 25686087 Free PMC article.
On the lag phase in amyloid fibril formation.
Arosio P, Knowles TP, Linse S. Arosio P, et al. Phys Chem Chem Phys. 2015 Mar 28;17(12):7606-18. doi: 10.1039/c4cp05563b. Phys Chem Chem Phys. 2015. PMID: 25719972 Free PMC article. Review.
Preventing peptide and protein misbehavior.
Arosio P, Meisl G, Andreasen M, Knowles TP. Arosio P, et al. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5267-8. doi: 10.1073/pnas.1505170112. Epub 2015 Apr 20. Proc Natl Acad Sci U S A. 2015. PMID: 25902542 Free PMC article. No abstract available.
451 results