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Inhibitory input directs astrocyte morphogenesis through glial GABABR.
Cheng YT, Luna-Figueroa E, Woo J, Chen HC, Lee ZF, Harmanci AS, Deneen B. Cheng YT, et al. Among authors: chen hc. Nature. 2023 May;617(7960):369-376. doi: 10.1038/s41586-023-06010-x. Epub 2023 Apr 26. Nature. 2023. PMID: 37100909 Free PMC article.
ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma.
Arabzade A, Zhao Y, Varadharajan S, Chen HC, Jessa S, Rivas B, Stuckert AJ, Solis M, Kardian A, Tlais D, Golbourn BJ, Stanton AJ, Chan YS, Olson C, Karlin KL, Kong K, Kupp R, Hu B, Injac SG, Ngo M, Wang PR, De León LA, Sahm F, Kawauchi D, Pfister SM, Lin CY, Hodges HC, Singh I, Westbrook TF, Chintagumpala MM, Blaney SM, Parsons DW, Pajtler KW, Agnihotri S, Gilbertson RJ, Yi J, Jabado N, Kleinman CL, Bertrand KC, Deneen B, Mack SC. Arabzade A, et al. Among authors: chen hc. Cancer Discov. 2021 Sep;11(9):2200-2215. doi: 10.1158/2159-8290.CD-20-1066. Epub 2021 Mar 19. Cancer Discov. 2021. PMID: 33741710 Free PMC article.
Sox9 directs divergent epigenomic states in brain tumor subtypes.
Sardar D, Chen HC, Reyes A, Varadharajan S, Jain A, Mohila C, Curry R, Lozzi B, Rajendran K, Cervantes A, Yu K, Jalali A, Rao G, Mack SC, Deneen B. Sardar D, et al. Among authors: chen hc. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2202015119. doi: 10.1073/pnas.2202015119. Epub 2022 Jul 15. Proc Natl Acad Sci U S A. 2022. PMID: 35858326 Free PMC article.
Activity-dependent induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation.
Sardar D, Cheng YT, Woo J, Choi DJ, Lee ZF, Kwon W, Chen HC, Lozzi B, Cervantes A, Rajendran K, Huang TW, Jain A, Arenkiel B, Maze I, Deneen B. Sardar D, et al. Among authors: chen hc. bioRxiv [Preprint]. 2023 Feb 27:2023.02.24.529904. doi: 10.1101/2023.02.24.529904. bioRxiv. 2023. Update in: Science. 2023 Jun 16;380(6650):eade0027. doi: 10.1126/science.ade0027 PMID: 36909526 Free PMC article. Updated. Preprint.
Remote neuronal activity drives glioma infiltration via Sema4f.
Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson M, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen B. Huang-Hobbs E, et al. Among authors: chen hc. bioRxiv [Preprint]. 2023 Mar 16:2023.03.15.532832. doi: 10.1101/2023.03.15.532832. bioRxiv. 2023. Update in: Nature. 2023 Jul;619(7971):844-850. doi: 10.1038/s41586-023-06267-2 PMID: 36993539 Free PMC article. Updated. Preprint.
The genomic landscape of familial glioma.
Choi DJ, Armstrong G, Lozzi B, Vijayaraghavan P, Plon SE, Wong TC, Boerwinkle E, Muzny DM, Chen HC, Gibbs RA, Ostrom QT, Melin B, Deneen B, Bondy ML; Gliogene Consortium; Genomics England Research Consortium; Bainbridge MN, Amos CI, Barnholtz-Sloan JS, Bernstein JL, Claus EB, Houlston RS, Il'yasova D, Jenkins RB, Johansen C, Lachance D, Lai R, Melin BS, Merrell RT, Olson SH, Sadetzki S, Schildkraut J, Shete S, Ambrose JC, Arumugam P, Bevers R, Bleda M, Boardman-Pretty F, Boustred CR, Brittain H, Brown MA, Caulfield MJ, Chan GC, Giess A, Griffin JN, Hamblin A, Henderson S, Hubbard TJP, Jackson R, Jones LJ, Kasperaviciute D, Kayikci M, Kousathanas A, Lahnstein L, Lakey A, Leigh SEA, Leong IUS, Lopez FJ, Maleady-Crowe F, McEntagart M, Minneci F, Mitchell J, Moutsianas L, Mueller M, Murugaesu N, Need AC, O'Donovan P, Odhams CA, Patch C, Perez-Gil D, Pereira MB, Pullinger J, Rahim T, Rendon A, Rogers T, Savage K, Sawant K, Scott RH, Siddiq A, Sieghart A, Smith SC, Sosinsky A, Stuckey A, Tanguy M, Taylor Tavares AL, Thomas ERA, Thompson SR, Tucci A, Welland MJ, Williams E, Witkowska K, Wood SM, Zarowiecki M. Choi DJ, et al. Among authors: chen hc. Sci Adv. 2023 Apr 28;9(17):eade2675. doi: 10.1126/sciadv.ade2675. Epub 2023 Apr 28. Sci Adv. 2023. PMID: 37115922 Free PMC article.
Remote neuronal activity drives glioma progression through SEMA4F.
Huang-Hobbs E, Cheng YT, Ko Y, Luna-Figueroa E, Lozzi B, Taylor KR, McDonald M, He P, Chen HC, Yang Y, Maleki E, Lee ZF, Murali S, Williamson MR, Choi D, Curry R, Bayley J, Woo J, Jalali A, Monje M, Noebels JL, Harmanci AS, Rao G, Deneen B. Huang-Hobbs E, et al. Among authors: chen hc. Nature. 2023 Jul;619(7971):844-850. doi: 10.1038/s41586-023-06267-2. Epub 2023 Jun 28. Nature. 2023. PMID: 37380778 Free PMC article.
Histone serotonylation regulates ependymoma tumorigenesis.
Chen HC, He P, McDonald M, Williamson MR, Varadharajan S, Lozzi B, Woo J, Choi DJ, Sardar D, Huang-Hobbs E, Sun H, Ippagunta SM, Jain A, Rao G, Merchant TE, Ellison DW, Noebels JL, Bertrand KC, Mack SC, Deneen B. Chen HC, et al. Nature. 2024 Aug;632(8026):903-910. doi: 10.1038/s41586-024-07751-z. Epub 2024 Jul 31. Nature. 2024. PMID: 39085609
4,171 results