Guthrie B - Search Results

1

Predicted structure and cell signaling of TAS2R14 reveal receptor hyper-flexibility for detecting diverse bitter tastes.

Tokmakova A, Kim D, Guthrie B, Kim SK, Goddard WA 3rd, Liggett SB. Tokmakova A, et al. Among authors: guthrie b. iScience. 2023 Mar 16;26(4):106422. doi: 10.1016/j.isci.2023.106422. eCollection 2023 Apr 21. iScience. 2023. PMID: 37096045 Free PMC article.

2

Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists.

Kim SK, Chen Y, Abrol R, Goddard WA 3rd, Guthrie B. Kim SK, et al. Among authors: guthrie b. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2568-2573. doi: 10.1073/pnas.1700001114. Epub 2017 Feb 22. Proc Natl Acad Sci U S A. 2017. PMID: 28228527 Free PMC article.

3

Predicted Structure of Fully Activated Tas1R3/1R3' Homodimer Bound to G Protein and Natural Sugars: Structural Insights into G Protein Activation by a Class C Sweet Taste Homodimer with Natural Sugars.

Mafi A, Kim SK, Chou KC, Güthrie B, Goddard WA 3rd. Mafi A, et al. Among authors: guthrie b. J Am Chem Soc. 2021 Oct 13;143(40):16824-16838. doi: 10.1021/jacs.1c08839. Epub 2021 Sep 29. J Am Chem Soc. 2021. PMID: 34585929

4

Synergic Effects in the Activation of the Sweet Receptor GPCR Heterodimer for Various Sweeteners Predicted Using Molecular Metadynamics Simulations.

Jang J, Kim SK, Guthrie B, Goddard WA 3rd. Jang J, et al. Among authors: guthrie b. J Agric Food Chem. 2021 Oct 20;69(41):12250-12261. doi: 10.1021/acs.jafc.1c03779. Epub 2021 Oct 6. J Agric Food Chem. 2021. PMID: 34613740

5

Predicted structure of fully activated human bitter taste receptor TAS2R4 complexed with G protein and agonists.

Yang MY, Mafi A, Kim SK, Goddard WA 3rd, Guthrie B. Yang MY, et al. Among authors: guthrie b. QRB Discov. 2021 Apr 8;2:e3. doi: 10.1017/qrd.2021.1. eCollection 2021. QRB Discov. 2021. PMID: 37529671 Free PMC article.

6

Ligand-Dependent and G Protein-Dependent Properties for the Sweet Taste Heterodimer, TAS1R2/1R3.

Kim SK, Guthrie B, Goddard WA 3rd. Kim SK, et al. Among authors: guthrie b. J Phys Chem B. 2024 Sep 19;128(37):8927-8932. doi: 10.1021/acs.jpcb.4c04610. Epub 2024 Sep 4. J Phys Chem B. 2024. PMID: 39231438 Free PMC article.

7

Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments.

Hao S, Guthrie B, Kim SK, Balanda S, Kubicek J, Murtaza B, Khan NA, Khakbaz P, Su J, Goddard WA 3rd. Hao S, et al. Among authors: guthrie b. Commun Chem. 2024 Oct 18;7(1):236. doi: 10.1038/s42004-024-01324-x. Commun Chem. 2024. PMID: 39424933 Free PMC article.

8

Pizza3: A general simulation framework to simulate food-mechanical and food-deconstruction problems.

Jenkinson W, Guthrie B, Flick D, Vitrac O. Jenkinson W, et al. Among authors: guthrie b. Food Res Int. 2024 Oct;194:114908. doi: 10.1016/j.foodres.2024.114908. Epub 2024 Aug 14. Food Res Int. 2024. PMID: 39232501 Free article.

9

Does remission of type 2 diabetes matter? A qualitative study of healthcare professionals' perspectives and views about supporting remission in primary care.

Captieux M, Guthrie B, Lawton J. Captieux M, et al. Among authors: guthrie b. Diabet Med. 2025 Jan 18:e15515. doi: 10.1111/dme.15515. Online ahead of print. Diabet Med. 2025. PMID: 39825625

10

A Digital Tool for Clinical Evidence-Driven Guideline Development by Studying Properties of Trial Eligible and Ineligible Populations: Development and Usability Study.

Mumtaz S, McMinn M, Cole C, Gao C, Hall C, Guignard-Duff M, Huang H, McAllister DA, Morales DR, Jefferson E, Guthrie B. Mumtaz S, et al. Among authors: guthrie b. J Med Internet Res. 2025 Jan 16;27:e52385. doi: 10.2196/52385. J Med Internet Res. 2025. PMID: 39819848 Free article.

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