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The rationale and study design of two phase II trials examining the effects of BI 685,509, a soluble guanylyl cyclase activator, on clinically significant portal hypertension in patients with compensated cirrhosis.
Reiberger T, Berzigotti A, Trebicka J, Ertle J, Gashaw I, Swallow R, Tomisser A. Reiberger T, et al. Among authors: gashaw i. Trials. 2023 Apr 24;24(1):293. doi: 10.1186/s13063-023-07291-3. Trials. 2023. PMID: 37095557 Free PMC article. Clinical Trial.
Variability of transient elastography-based spleen stiffness performed at 100 Hz.
Armandi A, Merizian T, Werner MM, Coxson HO, Sanavia T, Birolo G, Gashaw I, Ertle J, Michel M, Galle PR, Labenz C, Emrich T, Schattenberg JM. Armandi A, et al. Among authors: gashaw i. Eur Radiol Exp. 2023 Dec 12;7(1):79. doi: 10.1186/s41747-023-00393-2. Eur Radiol Exp. 2023. PMID: 38087079 Free PMC article.
Pharmacodynamics, pharmacokinetics and CYP3A4 interaction potential of the selective P2X3 receptor antagonist filapixant: A randomized multiple ascending-dose study in healthy young men.
Friedrich C, Singh D, Francke K, Klein S, Hetzel T, Zolk O, Gashaw I, Scheerans C, Morice A. Friedrich C, et al. Among authors: gashaw i. Br J Clin Pharmacol. 2024 Aug;90(8):2004-2018. doi: 10.1111/bcp.16091. Epub 2024 May 22. Br J Clin Pharmacol. 2024. PMID: 38775025 Clinical Trial.
Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis.
Hilpert J, Groettrup-Wolfers E, Kosturski H, Bennett L, Barnes CLK, Gude K, Gashaw I, Reif S, Steger-Hartmann T, Scheerans C, Solms A, Rottmann A, Mao G, Chapron C. Hilpert J, et al. Among authors: gashaw i. Drugs R D. 2023 Sep;23(3):221-237. doi: 10.1007/s40268-023-00427-5. Epub 2023 Jul 9. Drugs R D. 2023. PMID: 37422772 Free PMC article. Clinical Trial.
Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study.
Friedrich C, Francke K, Gashaw I, Scheerans C, Klein S, Fels L, Smith JA, Hummel T, Morice A. Friedrich C, et al. Among authors: gashaw i. Clin Pharmacokinet. 2022 Aug;61(8):1143-1156. doi: 10.1007/s40262-022-01126-1. Epub 2022 May 28. Clin Pharmacokinet. 2022. PMID: 35624408 Free PMC article. Clinical Trial.
36 results