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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness.
Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. Gu L, et al. Among authors: zhu y. Cell Metab. 2023 Jun 6;35(6):1009-1021.e9. doi: 10.1016/j.cmet.2023.03.021. Epub 2023 Apr 20. Cell Metab. 2023. PMID: 37084733 Free PMC article.
Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells.
Gu L, Zhu Y, Lee M, Nguyen A, Ryujin NT, Huang JY, Pandit SK, Chamseddine S, Xiao L, Mohamed YI, Kaseb AO, Karin M, Shalapour S. Gu L, et al. Among authors: zhu y. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2300706120. doi: 10.1073/pnas.2300706120. Epub 2023 May 1. Proc Natl Acad Sci U S A. 2023. PMID: 37126700 Free PMC article.
miR-148a inhibits colitis and colitis-associated tumorigenesis in mice.
Zhu Y, Gu L, Li Y, Lin X, Shen H, Cui K, Chen L, Zhou F, Zhao Q, Zhang J, Zhong B, Prochownik E, Li Y. Zhu Y, et al. Cell Death Differ. 2017 Dec;24(12):2199-2209. doi: 10.1038/cdd.2017.151. Epub 2017 Sep 29. Cell Death Differ. 2017. PMID: 28960206 Free PMC article.
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