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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness.
Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. Gu L, et al. Among authors: lee m, lee jh. Cell Metab. 2023 Jun 6;35(6):1009-1021.e9. doi: 10.1016/j.cmet.2023.03.021. Epub 2023 Apr 20. Cell Metab. 2023. PMID: 37084733 Free PMC article.
Sestrins at the crossroad between stress and aging.
Lee JH, Bodmer R, Bier E, Karin M. Lee JH, et al. Aging (Albany NY). 2010 Jun;2(6):369-74. doi: 10.18632/aging.100157. Aging (Albany NY). 2010. PMID: 20606249 Free PMC article. Review.
Stressin' Sestrins take an aging fight.
Budanov AV, Lee JH, Karin M. Budanov AV, et al. Among authors: lee jh. EMBO Mol Med. 2010 Oct;2(10):388-400. doi: 10.1002/emmm.201000097. EMBO Mol Med. 2010. PMID: 20878915 Free PMC article. Review.
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, Foretz M, Viollet B, Olefsky J, Karin M. Lee JH, et al. Cell Metab. 2012 Sep 5;16(3):311-21. doi: 10.1016/j.cmet.2012.08.004. Cell Metab. 2012. PMID: 22958918 Free PMC article.
Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.
Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J. Morrison A, et al. Among authors: lee jh. FASEB J. 2015 Feb;29(2):408-17. doi: 10.1096/fj.14-258814. Epub 2014 Nov 3. FASEB J. 2015. PMID: 25366347 Free PMC article.
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