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Page 1
FLT3 signaling inhibition abrogates opioid tolerance and hyperalgesia while preserving analgesia.
Jouvenel A, Tassou A, Thouaye M, Ruel J, Antri M, Leyris JP, Giraudin A, Mallié S, Sar C, Diouloufet L, Sonrier C, Daubeuf F, Bertin J, Alves S, Ventéo S, Frossard N, Carroll P, Mechaly I, Rognan D, Sokoloff P, Dallel R, Delmas P, Valmier J, Rivat C. Jouvenel A, et al. Among authors: thouaye m. Nat Commun. 2024 Nov 7;15(1):9633. doi: 10.1038/s41467-024-54054-y. Nat Commun. 2024. PMID: 39511220 Free PMC article.
The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice.
Becker LJ, Fillinger C, Waegaert R, Journée SH, Hener P, Ayazgok B, Humo M, Karatas M, Thouaye M, Gaikwad M, Degiorgis L, Santin MDN, Mondino M, Barrot M, Ibrahim EC, Turecki G, Belzeaux R, Veinante P, Harsan LA, Hugel S, Lutz PE, Yalcin I. Becker LJ, et al. Among authors: thouaye m. Nat Commun. 2023 Apr 17;14(1):2198. doi: 10.1038/s41467-023-37878-y. Nat Commun. 2023. PMID: 37069164 Free PMC article.
Activation of neuronal FLT3 promotes exaggerated sensorial and emotional pain-related behaviors facilitating the transition from acute to chronic pain.
Tassou A, Thouaye M, Gilabert D, Jouvenel A, Leyris JP, Sonrier C, Diouloufet L, Mechaly I, Mallié S, Bertin J, Chentouf M, Neiveyans M, Pugnière M, Martineau P, Robert B, Capdevila X, Valmier J, Rivat C. Tassou A, et al. Among authors: thouaye m. Prog Neurobiol. 2023 Mar;222:102405. doi: 10.1016/j.pneurobio.2023.102405. Epub 2023 Jan 13. Prog Neurobiol. 2023. PMID: 36646299 Free article.
High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators.
Hany R, Leyris JP, Bret G, Mallié S, Sar C, Thouaye M, Hamze A, Provot O, Sokoloff P, Valmier J, Villa P, Rognan D. Hany R, et al. Among authors: thouaye m. ACS Chem Biol. 2022 Mar 18;17(3):709-722. doi: 10.1021/acschembio.2c00048. Epub 2022 Feb 28. ACS Chem Biol. 2022. PMID: 35227060 Free article.