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Tracking of activated cTfh cells following sequential influenza vaccinations reveals transcriptional profile of clonotypes driving a vaccine-induced immune response.
Currenti J, Simmons J, Oakes J, Gaudieri S, Warren CM, Gangula R, Alves E, Ram R, Leary S, Armitage JD, Smith RM, Chopra A, Halasa NB, Pilkinton MA, Kalams SA. Currenti J, et al. Among authors: leary s. Front Immunol. 2023 Mar 29;14:1133781. doi: 10.3389/fimmu.2023.1133781. eCollection 2023. Front Immunol. 2023. PMID: 37063867 Free PMC article.
Cross-Reactivity to Mutated Viral Immune Targets Can Influence CD8+ T Cell Functionality: An Alternative Viral Adaptation Strategy.
Currenti J, Law BMP, Qin K, John M, Pilkinton MA, Bansal A, Leary S, Ram R, Chopra A, Gangula R, Yue L, Warren C, Barnett L, Alves E, McDonnell WJ, Sooda A, Heath SL, Mallal S, Goepfert P, Kalams SA, Gaudieri S. Currenti J, et al. Among authors: leary s. Front Immunol. 2021 Oct 26;12:746986. doi: 10.3389/fimmu.2021.746986. eCollection 2021. Front Immunol. 2021. PMID: 34764960 Free PMC article.
Deep sequence analysis of HIV adaptation following vertical transmission reveals the impact of immune pressure on the evolution of HIV.
Currenti J, Chopra A, John M, Leary S, McKinnon E, Alves E, Pilkinton M, Smith R, Barnett L, McDonnell WJ, Lucas M, Noel F, Mallal S, Conrad JA, Kalams SA, Gaudieri S. Currenti J, et al. Among authors: leary s. PLoS Pathog. 2019 Dec 10;15(12):e1008177. doi: 10.1371/journal.ppat.1008177. eCollection 2019 Dec. PLoS Pathog. 2019. PMID: 31821379 Free PMC article.
In chronic infection, HIV gag-specific CD4+ T cell receptor diversity is higher than CD8+ T cell receptor diversity and is associated with less HIV quasispecies diversity.
Pilkinton MA, McDonnell WJ, Barnett L, Chopra A, Gangula R, White KD, Leary S, Currenti J, Gaudieri S, Mallal SA, Kalams SA. Pilkinton MA, et al. Among authors: leary s. J Virol. 2021 Mar 25;95(8):e02380-20. doi: 10.1128/JVI.02380-20. Epub 2021 Feb 3. J Virol. 2021. PMID: 33536169 Free PMC article.
Single-cell analysis shows that adipose tissue of persons with both HIV and diabetes is enriched for clonal, cytotoxic, and CMV-specific CD4+ T cells.
Wanjalla CN, McDonnell WJ, Ram R, Chopra A, Gangula R, Leary S, Mashayekhi M, Simmons JD, Warren CM, Bailin S, Gabriel CL, Guo L, Furch BD, Lima MC, Woodward BO, Hannah L, Pilkinton MA, Fuller DT, Kawai K, Virmani R, Finn AV, Hasty AH, Mallal SA, Kalams SA, Koethe JR. Wanjalla CN, et al. Among authors: leary s. Cell Rep Med. 2021 Feb 16;2(2):100205. doi: 10.1016/j.xcrm.2021.100205. eCollection 2021 Feb 16. Cell Rep Med. 2021. PMID: 33665640 Free PMC article.
Visual Genomics Analysis Studio as a Tool to Analyze Multiomic Data.
Hertzman RJ, Deshpande P, Leary S, Li Y, Ram R, Chopra A, Cooper D, Watson M, Palubinsky AM, Mallal S, Gibson A, Phillips EJ. Hertzman RJ, et al. Among authors: leary s. Front Genet. 2021 Jun 17;12:642012. doi: 10.3389/fgene.2021.642012. eCollection 2021. Front Genet. 2021. PMID: 34220932 Free PMC article.
Single-cell transcriptomics reveal polyclonal memory T-cell responses in skin with positive abacavir patch test results.
Redwood AJ, Rwandamuriye F, Chopra A, Leary S, Ram R, McDonnell W, Konvinse K, White K, Pavlos R, Koelle DM, Mallal S, Phillips EJ. Redwood AJ, et al. Among authors: leary s. J Allergy Clin Immunol. 2019 Nov;144(5):1413-1416.e7. doi: 10.1016/j.jaci.2019.09.013. Epub 2019 Sep 28. J Allergy Clin Immunol. 2019. PMID: 31574267 Free PMC article. No abstract available.
New genetic predictors for abacavir tolerance in HLA-B*57:01 positive individuals.
Pavlos R, Deshpande P, Chopra A, Leary S, Strautins K, Nolan D, Thorborn D, Shaefer M, Rauch A, Dunn D, Montaner J, Rachlis A, Almeida CA, Choo L, James I, Redwood AJ, Li Y, Gaudieri S, Mallal SA, Phillips EJ. Pavlos R, et al. Among authors: leary s. Hum Immunol. 2020 Jun;81(6):300-304. doi: 10.1016/j.humimm.2020.02.011. Epub 2020 Mar 12. Hum Immunol. 2020. PMID: 32173028 Free PMC article.
435 results