Chen X - Search Results

1

Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease.

Li YD, Luo YJ, Xie L, Tart DS, Sheehy RN, Zhang L, Coleman LG Jr, Chen X, Song J. Li YD, et al. Among authors: chen x. Cell Stem Cell. 2023 Apr 6;30(4):415-432.e6. doi: 10.1016/j.stem.2023.02.006. Cell Stem Cell. 2023. PMID: 37028406 Free PMC article.

2

Nonlytic Quasi-Enveloped Hepatovirus Release Is Facilitated by pX Protein Interaction with the E3 Ubiquitin Ligase ITCH.

Shirasaki T, González-López O, McKnight KL, Xie L, Shiota T, Chen X, Feng H, Lemon SM. Shirasaki T, et al. Among authors: chen x. J Virol. 2022 Nov 9;96(21):e0119522. doi: 10.1128/jvi.01195-22. Epub 2022 Oct 26. J Virol. 2022. PMID: 36286484 Free PMC article.

3

Histone H3 proline 16 hydroxylation regulates mammalian gene expression.

Liu X, Wang J, Boyer JA, Gong W, Zhao S, Xie L, Wu Q, Zhang C, Jain K, Guo Y, Rodriguez J, Li M, Uryu H, Liao C, Hu L, Zhou J, Shi X, Tsai YH, Yan Q, Luo W, Chen X, Strahl BD, von Kriegsheim A, Zhang Q, Wang GG, Baldwin AS, Zhang Q. Liu X, et al. Among authors: chen x. Nat Genet. 2022 Nov;54(11):1721-1735. doi: 10.1038/s41588-022-01212-x. Epub 2022 Nov 8. Nat Genet. 2022. PMID: 36347944 Free PMC article.

4

Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets.

Xiong Y, Zhong Y, Yim H, Yang X, Park KS, Xie L, Poulikakos PI, Han X, Xiong Y, Chen X, Liu J, Jin J. Xiong Y, et al. Among authors: chen x. J Am Chem Soc. 2022 Dec 14;144(49):22622-22632. doi: 10.1021/jacs.2c09255. Epub 2022 Nov 30. J Am Chem Soc. 2022. PMID: 36448571 Free PMC article.

5

Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer.

Sun N, Kabir M, Lee Y, Xie L, Hu X, Velez J, Chen X, Kaniskan HÜ, Jin J. Sun N, et al. Among authors: chen x. J Med Chem. 2023 Jan 12;66(1):596-610. doi: 10.1021/acs.jmedchem.2c01505. Epub 2022 Dec 20. J Med Chem. 2023. PMID: 36538511 Free PMC article.

6

Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins.

Wang Z, Liu J, Chen H, Qiu X, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W. Wang Z, et al. Among authors: chen h, chen x. J Am Chem Soc. 2023 May 17;145(19):10872-10879. doi: 10.1021/jacs.3c02783. Epub 2023 May 4. J Am Chem Soc. 2023. PMID: 37141574 Free PMC article.

7

Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2.

Wang Z, Liu J, Qiu X, Zhang D, Inuzuka H, Chen L, Chen H, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W. Wang Z, et al. Among authors: chen l, chen h, chen x. J Am Chem Soc. 2023 Oct 11;145(40):21871-21878. doi: 10.1021/jacs.3c06023. Epub 2023 Sep 29. J Am Chem Soc. 2023. PMID: 37774414 Free PMC article.

8

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.

Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X. Muneer A, et al. Among authors: chen x. Cell Chem Biol. 2023 Dec 21;30(12):1525-1541.e7. doi: 10.1016/j.chembiol.2023.09.012. Epub 2023 Oct 19. Cell Chem Biol. 2023. PMID: 37858336 Free PMC article.

9

Novel brain-penetrant inhibitor of G9a methylase blocks Alzheimer's disease proteopathology for precision medication.

Xie L, Sheehy RN, Xiong Y, Muneer A, Wrobel JA, Park KS, Velez J, Liu J, Luo YJ, Li YD, Quintanilla L, Li Y, Xu C, Deshmukh M, Wen Z, Jin J, Song J, Chen X. Xie L, et al. Among authors: chen x. medRxiv [Preprint]. 2023 Oct 26:2023.10.25.23297491. doi: 10.1101/2023.10.25.23297491. medRxiv. 2023. PMID: 37961307 Free PMC article. Preprint.

10

Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer.

Yu X, Li D, Kottur J, Kim HS, Herring LE, Yu Y, Xie L, Hu X, Chen X, Cai L, Liu J, Aggarwal AK, Wang GG, Jin J. Yu X, et al. Among authors: chen x. J Med Chem. 2023 Dec 14;66(23):16168-16186. doi: 10.1021/acs.jmedchem.3c01521. Epub 2023 Nov 29. J Med Chem. 2023. PMID: 38019706 Free PMC article.

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