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Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist.
Karstens WFJ, M B P Menge W, Martens G, Op Het Veld SJN, Th H van Eupen J, Demon M, van Achterberg TAE, Arisse-Thijssen MJ, Santegoeds-Lenssen EWH, van der Lee MMC, Ubink R, Arends RJ, Sesink A, Blomenröhr M, Marco Timmers C. Karstens WFJ, et al. Bioorg Med Chem. 2023 Apr 15;84:117258. doi: 10.1016/j.bmc.2023.117258. Epub 2023 Mar 23. Bioorg Med Chem. 2023. PMID: 37001244 Free article.