Huang ZS - Search Results

1

Discovery of the First Raptor (Regulatory-Associated Protein of mTOR) Inhibitor as a New Type of Antiadipogenic Agent.

Yan XL, Pan YH, Fan RZ, Song QQ, Li S, Huang JL, Li W, Huang D, Yuan FY, Tang GH, Rao Y, Huang ZS, Yin S. Yan XL, et al. Among authors: huang jl, huang d, huang zs. J Med Chem. 2023 Apr 27;66(8):5839-5858. doi: 10.1021/acs.jmedchem.3c00067. Epub 2023 Apr 4. J Med Chem. 2023. PMID: 37014798

2

Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.

Wu WB, Ou JB, Huang ZH, Chen SB, Ou TM, Tan JH, Li D, Shen LL, Huang SL, Gu LQ, Huang ZS. Wu WB, et al. Among authors: huang zh, huang sl, huang zs. Eur J Med Chem. 2011 Aug;46(8):3339-47. doi: 10.1016/j.ejmech.2011.04.059. Epub 2011 May 5. Eur J Med Chem. 2011. PMID: 21600681

3

Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5' Untranslated Region (UTR) of Its mRNA.

Dai J, Liu ZQ, Wang XQ, Lin J, Yao PF, Huang SL, Ou TM, Tan JH, Li D, Gu LQ, Huang ZS. Dai J, et al. Among authors: huang sl, huang zs. J Med Chem. 2015 May 14;58(9):3875-91. doi: 10.1021/acs.jmedchem.5b00139. Epub 2015 Apr 15. J Med Chem. 2015. PMID: 25822852

4

Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes.

Rao Y, Liu H, Gao L, Yu H, Tan JH, Ou TM, Huang SL, Gu LQ, Ye JM, Huang ZS. Rao Y, et al. Among authors: huang sl, huang zs. Bioorg Med Chem. 2015 Aug 1;23(15):4719-4727. doi: 10.1016/j.bmc.2015.05.057. Epub 2015 Jun 5. Bioorg Med Chem. 2015. PMID: 26088335

5

Synthesis and Biological Evaluation of Novel Bouchardatine Derivatives as Potential Adipogenesis/Lipogenesis Inhibitors for Antiobesity Treatment.

Rao Y, Liu H, Gao L, Yu H, Ou TM, Tan JH, Huang SL, Wang HG, Li D, Gu LQ, Ye JM, Huang ZS. Rao Y, et al. Among authors: huang sl, huang zs. J Med Chem. 2015 Dec 10;58(23):9395-413. doi: 10.1021/acs.jmedchem.5b01566. Epub 2015 Dec 1. J Med Chem. 2015. PMID: 26572282

6

Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.

Li PH, Zeng P, Chen SB, Yao PF, Mai YW, Tan JH, Ou TM, Huang SL, Li D, Gu LQ, Huang ZS. Li PH, et al. Among authors: huang sl, huang zs. J Med Chem. 2016 Jan 14;59(1):238-52. doi: 10.1021/acs.jmedchem.5b01284. Epub 2015 Dec 21. J Med Chem. 2016. PMID: 26649766

7

Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex.

Shan C, Yan JW, Wang YQ, Che T, Huang ZL, Chen AC, Yao PF, Tan JH, Li D, Ou TM, Gu LQ, Huang ZS. Shan C, et al. Among authors: huang zl, huang zs. J Med Chem. 2017 Feb 23;60(4):1292-1308. doi: 10.1021/acs.jmedchem.6b01218. Epub 2017 Feb 13. J Med Chem. 2017. PMID: 28128954

8

Analogues of xanthones--Chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates.

Cai CY, Rao L, Rao Y, Guo JX, Xiao ZZ, Cao JY, Huang ZS, Wang B. Cai CY, et al. Among authors: huang zs. Eur J Med Chem. 2017 Apr 21;130:51-59. doi: 10.1016/j.ejmech.2017.02.007. Epub 2017 Feb 7. Eur J Med Chem. 2017. PMID: 28242551

9

Natural alkaloid bouchardatine ameliorates metabolic disorders in high-fat diet-fed mice by stimulating the sirtuin 1/liver kinase B-1/AMPK axis.

Rao Y, Yu H, Gao L, Lu YT, Xu Z, Liu H, Gu LQ, Ye JM, Huang ZS. Rao Y, et al. Among authors: huang zs. Br J Pharmacol. 2017 Aug;174(15):2457-2470. doi: 10.1111/bph.13855. Epub 2017 Jun 21. Br J Pharmacol. 2017. PMID: 28493443 Free PMC article.

10

Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry.

Zeng DY, Kuang GT, Wang SK, Peng W, Lin SL, Zhang Q, Su XX, Hu MH, Wang H, Tan JH, Huang ZS, Gu LQ, Ou TM. Zeng DY, et al. Among authors: huang zs. J Med Chem. 2017 Jul 13;60(13):5407-5423. doi: 10.1021/acs.jmedchem.7b00016. Epub 2017 Jun 16. J Med Chem. 2017. PMID: 28514170

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