Brea J - Search Results

1

Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT₆ receptor interaction.

Asproni B, Catto M, Loriga G, Murineddu G, Corona P, Purgatorio R, Cichero E, Fossa P, Scarano N, Martínez AL, Brea J, Pinna GA. Asproni B, et al. Among authors: brea j. Bioorg Med Chem. 2023 Apr 15;84:117256. doi: 10.1016/j.bmc.2023.117256. Epub 2023 Mar 21. Bioorg Med Chem. 2023. PMID: 37003157 Free article.

2

Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines.

Martínez A, Gutiérrez-de-Terán H, Brea J, Raviña E, Loza MI, Cadavid MI, Sanz F, Vidal B, Segarra V, Sotelo E. Martínez A, et al. Among authors: brea j. Bioorg Med Chem. 2008 Feb 15;16(4):2103-13. doi: 10.1016/j.bmc.2007.10.103. Epub 2008 Jan 24. Bioorg Med Chem. 2008. PMID: 18249548

3

Computer-aided structure-based design of multitarget leads for Alzheimer's disease.

Domínguez JL, Fernández-Nieto F, Castro M, Catto M, Paleo MR, Porto S, Sardina FJ, Brea JM, Carotti A, Villaverde MC, Sussman F. Domínguez JL, et al. J Chem Inf Model. 2015 Jan 26;55(1):135-48. doi: 10.1021/ci500555g. Epub 2014 Dec 24. J Chem Inf Model. 2015. PMID: 25483751

4

Multitarget-directed tricyclic pyridazinones as G protein-coupled receptor ligands and cholinesterase inhibitors.

Pau A, Catto M, Pinna G, Frau S, Murineddu G, Asproni B, Curzu MM, Pisani L, Leonetti F, Loza MI, Brea J, Pinna GA, Carotti A. Pau A, et al. Among authors: brea j. ChemMedChem. 2015 Jun;10(6):1054-70. doi: 10.1002/cmdc.201500124. Epub 2015 Apr 29. ChemMedChem. 2015. PMID: 25924828

5

Enantiospecific Recognition at the A_2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates.

Carbajales C, Azuaje J, Oliveira A, Loza MI, Brea J, Cadavid MI, Masaguer CF, García-Mera X, Gutiérrez-de-Terán H, Sotelo E. Carbajales C, et al. Among authors: brea j. J Med Chem. 2017 Apr 27;60(8):3372-3382. doi: 10.1021/acs.jmedchem.7b00138. Epub 2017 Apr 11. J Med Chem. 2017. PMID: 28368607

6

A Positive Allosteric Modulator of the Serotonin 5-HT_2C Receptor for Obesity.

García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, Brea J, Loza MI, Alén F, Botta J, McCormick PJ, Ballesteros JA, Benhamú B, Rodríguez de Fonseca F, López-Rodríguez ML. García-Cárceles J, et al. Among authors: brea j. J Med Chem. 2017 Dec 14;60(23):9575-9584. doi: 10.1021/acs.jmedchem.7b00994. Epub 2017 Nov 17. J Med Chem. 2017. PMID: 29116785

7

A New Model of Sensorial Neuron-Like Cells for HTS of Novel Analgesics for Neuropathic Pain.

Martínez AL, Brea J, Monroy X, Merlos M, Burgueño J, Loza MI. Martínez AL, et al. Among authors: brea j. SLAS Discov. 2019 Feb;24(2):158-168. doi: 10.1177/2472555218810323. Epub 2018 Nov 1. SLAS Discov. 2019. PMID: 30383474 Free article.

8

2-Aryladenine derivatives as a potent scaffold for A₁, A₃ and dual A₁/A₃ adenosine receptor antagonists: Synthesis and structure-activity relationships.

Areias F, Correia C, Rocha A, Brea J, Castro M, Loza MI, Proença MF, Carvalho MA. Areias F, et al. Among authors: brea j. Bioorg Med Chem. 2019 Aug 15;27(16):3551-3558. doi: 10.1016/j.bmc.2019.06.034. Epub 2019 Jun 20. Bioorg Med Chem. 2019. PMID: 31280999

9

Trifluorinated Pyrimidine-Based A_2B Antagonists: Optimization and Evidence of Stereospecific Recognition.

Mallo-Abreu A, Majellaro M, Jespers W, Azuaje J, Caamaño O, García-Mera X, Brea JM, Loza MI, Gutiérrez-de-Terán H, Sotelo E. Mallo-Abreu A, et al. Among authors: brea jm. J Med Chem. 2019 Oct 24;62(20):9315-9330. doi: 10.1021/acs.jmedchem.9b01340. Epub 2019 Oct 4. J Med Chem. 2019. PMID: 31557025

10

Essential role of the C148-C227 disulphide bridge in the human 5-HT_2A homodimeric receptor.

Cimadevila M, Gómez-García L, Martínez AL, Iglesias A, López-Giménez J, Castro M, Cadavid MI, Loza MI, Brea J. Cimadevila M, et al. Among authors: brea j. Biochem Pharmacol. 2020 Jul;177:113985. doi: 10.1016/j.bcp.2020.113985. Epub 2020 Apr 18. Biochem Pharmacol. 2020. PMID: 32311347

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