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Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression.
Giansante G, Mazzoleni S, Zippo AG, Ponzoni L, Ghilardi A, Maiellano G, Lewerissa E, van Hugte E, Nadif Kasri N, Francolini M, Sala M, Murru L, Bassani S, Passafaro M. Giansante G, et al. Among authors: mazzoleni s. Mol Psychiatry. 2024 Jun;29(6):1710-1725. doi: 10.1038/s41380-023-02022-1. Epub 2023 Mar 30. Mol Psychiatry. 2024. PMID: 36997609 Free PMC article.
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.
Gerosa L, Mazzoleni S, Rusconi F, Longaretti A, Lewerissa E, Pelucchi S, Murru L, Giannelli SG, Broccoli V, Marcello E, Kasri NN, Battaglioli E, Passafaro M, Bassani S. Gerosa L, et al. Among authors: mazzoleni s. Cell Rep. 2022 May 24;39(8):110857. doi: 10.1016/j.celrep.2022.110857. Cell Rep. 2022. PMID: 35613587 Free PMC article.
Perturbation of Cortical Excitability in a Conditional Model of PCDH19 Disorder.
Lamers D, Landi S, Mezzena R, Baroncelli L, Pillai V, Cruciani F, Migliarini S, Mazzoleni S, Pasqualetti M, Passafaro M, Bassani S, Ratto GM. Lamers D, et al. Among authors: mazzoleni s. Cells. 2022 Jun 16;11(12):1939. doi: 10.3390/cells11121939. Cells. 2022. PMID: 35741068 Free PMC article.
269 results