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Disruption of the autism-associated Pcdh9 gene leads to transcriptional alterations, synapse overgrowth, and defective network activity in the CA1.
Miozzo F, Murru L, Maiellano G, di Iasio I, Zippo AG, Zambrano Avendano A, Metodieva VD, Riccardi S, D'Aliberti D, Spinelli S, Canu T, Chaabane L, Hirano S, Kas MJH, Francolini M, Piazza R, Moretto E, Passafaro M. Miozzo F, et al. Among authors: maiellano g. J Neurosci. 2024 Nov 18;44(50):e0491242024. doi: 10.1523/JNEUROSCI.0491-24.2024. Online ahead of print. J Neurosci. 2024. PMID: 39557582
Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression.
Giansante G, Mazzoleni S, Zippo AG, Ponzoni L, Ghilardi A, Maiellano G, Lewerissa E, van Hugte E, Nadif Kasri N, Francolini M, Sala M, Murru L, Bassani S, Passafaro M. Giansante G, et al. Among authors: maiellano g. Mol Psychiatry. 2024 Jun;29(6):1710-1725. doi: 10.1038/s41380-023-02022-1. Epub 2023 Mar 30. Mol Psychiatry. 2024. PMID: 36997609 Free PMC article.