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Constitutively synergistic multiagent drug formulations targeting MERTK, FLT3, and BCL-2 for treatment of AML.
Kelvin JM, Jain J, Thapa A, Qui M, Birnbaum LA, Moore SG, Zecca H, Summers RJ, Costanza E, Uricoli B, Wang X, Jui NT, Fu H, Du Y, DeRyckere D, Graham DK, Dreaden EC. Kelvin JM, et al. Among authors: deryckere d. bioRxiv [Preprint]. 2023 Mar 15:2023.03.13.531236. doi: 10.1101/2023.03.13.531236. bioRxiv. 2023. Update in: Pharm Res. 2023 Sep;40(9):2133-2146. doi: 10.1007/s11095-023-03596-9 PMID: 36993676 Free PMC article. Updated. Preprint.
Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia.
Pillsbury CE, Dougan J, Rabe JL, Fonseca JA, Zhou C, Evans AN, Abukharma H, Ichoku O, Gonzalez-Flamenco G, Park SI, Aljudi A, DeRyckere D, Castellino SM, Rafiq S, Langermann S, Liu LN, Henry CJ, Porter CC. Pillsbury CE, et al. Among authors: deryckere d. Cancer Res Commun. 2023 Jul 17;3(7):1248-1259. doi: 10.1158/2767-9764.CRC-23-0056. eCollection 2023 Jul. Cancer Res Commun. 2023. PMID: 37465593 Free PMC article.
Molecular pathways: MERTK signaling in cancer.
Cummings CT, Deryckere D, Earp HS, Graham DK. Cummings CT, et al. Among authors: deryckere d. Clin Cancer Res. 2013 Oct 1;19(19):5275-80. doi: 10.1158/1078-0432.CCR-12-1451. Epub 2013 Jul 5. Clin Cancer Res. 2013. PMID: 23833304 Free PMC article. Review.
The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia.
Minson KA, Smith CC, DeRyckere D, Libbrecht C, Lee-Sherick AB, Huey MG, Lasater EA, Kirkpatrick GD, Stashko MA, Zhang W, Jordan CT, Kireev D, Wang X, Frye SV, Earp HS, Shah NP, Graham DK. Minson KA, et al. Among authors: deryckere d. JCI Insight. 2016 Mar;1(3):e85630. doi: 10.1172/jci.insight.85630. JCI Insight. 2016. PMID: 27158668 Free PMC article.
74 results