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Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade.
Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Huerta Uribe A, Shokry E, Young AL, Lilla S, Kim M, Park T, Manchon JL, Rodríguez-Antona C, Walters RC, Springett RJ, Blaza JN, Zanivan S, Sumpton D, Roberts EW, Reznik E, Gammage PA. Mahmood M, et al. Among authors: sumpton d. bioRxiv [Preprint]. 2023 Mar 23:2023.03.21.533091. doi: 10.1101/2023.03.21.533091. bioRxiv. 2023. Update in: Nat Cancer. 2024 Apr;5(4):659-672. doi: 10.1038/s43018-023-00721-w PMID: 36993533 Free PMC article. Updated. Preprint.
Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.
Port J, Muthalagu N, Raja M, Ceteci F, Monteverde T, Kruspig B, Hedley A, Kalna G, Lilla S, Neilson L, Brucoli M, Gyuraszova K, Tait-Mulder J, Mezna M, Svambaryte S, Bryson A, Sumpton D, McVie A, Nixon C, Drysdale M, Esumi H, Murray GI, Sansom OJ, Zanivan SR, Murphy DJ. Port J, et al. Among authors: sumpton d. Cancer Discov. 2018 May;8(5):632-647. doi: 10.1158/2159-8290.CD-17-0533. Epub 2018 Mar 2. Cancer Discov. 2018. PMID: 29500295 Free PMC article.
Formate induces a metabolic switch in nucleotide and energy metabolism.
Oizel K, Tait-Mulder J, Fernandez-de-Cossio-Diaz J, Pietzke M, Brunton H, Lilla S, Dhayade S, Athineos D, Blanco GR, Sumpton D, Mackay GM, Blyth K, Zanivan SR, Meiser J, Vazquez A. Oizel K, et al. Among authors: sumpton d. Cell Death Dis. 2020 May 4;11(5):310. doi: 10.1038/s41419-020-2523-z. Cell Death Dis. 2020. PMID: 32366892 Free PMC article.
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.
Blomme A, Ford CA, Mui E, Patel R, Ntala C, Jamieson LE, Planque M, McGregor GH, Peixoto P, Hervouet E, Nixon C, Salji M, Gaughan L, Markert E, Repiscak P, Sumpton D, Blanco GR, Lilla S, Kamphorst JJ, Graham D, Faulds K, MacKay GM, Fendt SM, Zanivan S, Leung HY. Blomme A, et al. Among authors: sumpton d. Nat Commun. 2020 May 19;11(1):2508. doi: 10.1038/s41467-020-16126-7. Nat Commun. 2020. PMID: 32427840 Free PMC article.
Impact of Formate Supplementation on Body Weight and Plasma Amino Acids.
Dhayade S, Pietzke M, Wiesheu R, Tait-Mulder J, Athineos D, Sumpton D, Coffelt S, Blyth K, Vazquez A. Dhayade S, et al. Among authors: sumpton d. Nutrients. 2020 Jul 22;12(8):2181. doi: 10.3390/nu12082181. Nutrients. 2020. PMID: 32708052 Free PMC article.
THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer.
Blomme A, Peter C, Mui E, Rodriguez Blanco G, An N, Mason LM, Jamieson LE, McGregor GH, Lilla S, Ntala C, Patel R, Thiry M, Kung SHY, Leclercq M, Ford CA, Rushworth LK, McGarry DJ, Mason S, Repiscak P, Nixon C, Salji MJ, Markert E, MacKay GM, Kamphorst JJ, Graham D, Faulds K, Fazli L, Gleave ME, Avezov E, Edwards J, Yin H, Sumpton D, Blyth K, Close P, Murphy DJ, Zanivan S, Leung HY. Blomme A, et al. Among authors: sumpton d. EMBO Mol Med. 2022 Mar 7;14(3):e14764. doi: 10.15252/emmm.202114764. Epub 2022 Jan 11. EMBO Mol Med. 2022. PMID: 35014179 Free PMC article.
Multi-omics & pathway analysis identify potential roles for tumor N-acetyl aspartate accumulation in murine models of castration-resistant prostate cancer.
Salji MJ, Blomme A, Däbritz JHM, Repiscak P, Lilla S, Patel R, Sumpton D, van den Broek NJF, Daly R, Zanivan S, Leung HY. Salji MJ, et al. Among authors: sumpton d. iScience. 2022 Mar 11;25(4):104056. doi: 10.1016/j.isci.2022.104056. eCollection 2022 Apr 15. iScience. 2022. PMID: 35345457 Free PMC article.
91 results