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Viral Nucleases.
Wang Z, Geraghty RJ. Wang Z, et al. Viruses. 2023 Mar 13;15(3):740. doi: 10.3390/v15030740. Viruses. 2023. PMID: 36992449 Free PMC article.
Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.
Kankanala J, Wang Y, Geraghty RJ, Wang Z. Kankanala J, et al. Among authors: wang z, wang y. ChemMedChem. 2018 Aug 20;13(16):1658-1663. doi: 10.1002/cmdc.201800283. Epub 2018 Jul 20. ChemMedChem. 2018. PMID: 29968426
However, inhibitors of the endonuclease activity of the C terminus of pUL89 (pUL89-C) were unknown before our recently characterized hydroxypyridonecarboxylic acid (HPCA) hit 7 r (1-(3-chloro-4-fluorobenzyl)-5-hydroxy-4-oxo-1,4-dihydropyridine-3-carboxylic acid; numbered as 10 k …
However, inhibitors of the endonuclease activity of the C terminus of pUL89 (pUL89-C) were unknown before our recently characterized hydroxy …
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