Metwally K - Search Results

1

The Unusual Architecture of RNA-Dependent RNA Polymerase (RdRp)'s Catalytic Chamber Provides a Potential Strategy for Combination Therapy against COVID-19.

Metwally K, Abo-Dya NE, Alahmdi MI, Albalawi MZ, Yahya G, Aljoundi A, Salifu EY, Elamin G, Ibrahim MAA, Sayed Y, Fanucchi S, Soliman MES. Metwally K, et al. Molecules. 2023 Mar 20;28(6):2806. doi: 10.3390/molecules28062806. Molecules. 2023. PMID: 36985777 Free PMC article.

2

Ketanserin and spiperone as templates for novel serotonin 5-HT(2A) antagonists.

Glennon RA, Metwally K, Dukat M, Ismaiel AM, De los Angeles J, Herndon J, Teitler M, Khorana N. Glennon RA, et al. Among authors: metwally k. Curr Top Med Chem. 2002 Jun;2(6):539-58. doi: 10.2174/1568026023393787. Curr Top Med Chem. 2002. PMID: 12052193 Review.

3

Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase.

Crespo I, Giménez-Dejoz J, Porté S, Cousido-Siah A, Mitschler A, Podjarny A, Pratsinis H, Kletsas D, Parés X, Ruiz FX, Metwally K, Farrés J. Crespo I, et al. Among authors: metwally k. Eur J Med Chem. 2018 May 25;152:160-174. doi: 10.1016/j.ejmech.2018.04.015. Epub 2018 Apr 12. Eur J Med Chem. 2018. PMID: 29705708

4

Synthesis, in-vitro cytotoxicity, and a preliminary structure-activity relationship investigation of pyrimido[4,5-c]quinoline-1(2H)-ones.

Metwally K, Khalil A, Pratsinis H, Kletsas D. Metwally K, et al. Arch Pharm (Weinheim). 2010 Aug;343(8):465-72. doi: 10.1002/ardp.200900281. Arch Pharm (Weinheim). 2010. PMID: 20803623

5

A novel scaffold to fight Pseudomonas aeruginosa pyocyanin production: early steps to novel antivirulence drugs.

Froes TQ, Guido RV, Metwally K, Castilho MS. Froes TQ, et al. Among authors: metwally k. Future Med Chem. 2020 Aug;12(16):1489-1503. doi: 10.4155/fmc-2019-0351. Epub 2020 Aug 10. Future Med Chem. 2020. PMID: 32772556

6

Quinazolinone-based rhodanine-3-acetic acids as potent aldose reductase inhibitors: Synthesis, functional evaluation and molecular modeling study.

El-Sayed S, Metwally K, El-Shanawani AA, Abdel-Aziz LM, El-Rashedy AA, Soliman MES, Quattrini L, Coviello V, la Motta C. El-Sayed S, et al. Among authors: metwally k. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4760-4764. doi: 10.1016/j.bmcl.2017.08.050. Epub 2017 Aug 24. Bioorg Med Chem Lett. 2017. PMID: 28935265

7

Novel quinazolinone-based 2,4-thiazolidinedione-3-acetic acid derivatives as potent aldose reductase inhibitors.

Metwally K, Pratsinis H, Kletsas D, Quattrini L, Coviello V, Motta C, El-Rashedy AA, Soliman ME. Metwally K, et al. Future Med Chem. 2017 Dec;9(18):2147-2166. doi: 10.4155/fmc-2017-0149. Epub 2017 Nov 3. Future Med Chem. 2017. PMID: 29098865

8

Profiling the physiological pitfalls of anti-hepatitis C direct-acting agents in budding yeast.

Yahya G, Hashem Mohamed N, Pijuan J, Seleem NM, Mosbah R, Hess S, Abdelmoaty AA, Almeer R, Abdel-Daim MM, Shulaywih Alshaman H, Juraiby I, Metwally K, Storchova Z. Yahya G, et al. Among authors: metwally k. Microb Biotechnol. 2021 Sep;14(5):2199-2213. doi: 10.1111/1751-7915.13904. Epub 2021 Aug 11. Microb Biotechnol. 2021. PMID: 34378349 Free PMC article.

9

Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive Review of Randomised Controlled Trials.

Popoviciu MS, Păduraru L, Yahya G, Metwally K, Cavalu S. Popoviciu MS, et al. Among authors: metwally k. Int J Mol Sci. 2023 Jun 21;24(13):10449. doi: 10.3390/ijms241310449. Int J Mol Sci. 2023. PMID: 37445623 Free PMC article. Review.

10

Pyrrolo[2,3-D]Pyrimidines as EGFR and VEGFR Kinase Inhibitors: A Comprehensive SAR Review.

Metwally K, Abo-Dya NE. Metwally K, et al. Curr Med Chem. 2024;31(36):5918-5936. doi: 10.2174/0929867331666230815115111. Curr Med Chem. 2024. PMID: 37581522 Review.

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