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Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Read KA, Jones DM, Pokhrel S, Hales EDS, Varkey A, Tuazon JA, Eisele CD, Abdouni O, Saadey A, Leonard MR, Warren RT, Powell MD, Boss JM, Hemann EA, Yount JS, Xin G, Ghoneim HE, Lio CJ, Freud AG, Collins PL, Oestreich KJ. Read KA, et al. Among authors: oestreich kj. Nat Commun. 2023 Mar 24;14(1):1652. doi: 10.1038/s41467-023-37420-0. Nat Commun. 2023. PMID: 36964178 Free PMC article.
High-frequency irreversible electroporation is an effective tumor ablation strategy that induces immunologic cell death and promotes systemic anti-tumor immunity.
Ringel-Scaia VM, Beitel-White N, Lorenzo MF, Brock RM, Huie KE, Coutermarsh-Ott S, Eden K, McDaniel DK, Verbridge SS, Rossmeisl JH Jr, Oestreich KJ, Davalos RV, Allen IC. Ringel-Scaia VM, et al. Among authors: oestreich kj. EBioMedicine. 2019 Jun;44:112-125. doi: 10.1016/j.ebiom.2019.05.036. Epub 2019 May 23. EBioMedicine. 2019. PMID: 31130474 Free PMC article.
Bcl-6 directly represses the gene program of the glycolysis pathway.
Oestreich KJ, Read KA, Gilbertson SE, Hough KP, McDonald PW, Krishnamoorthy V, Weinmann AS. Oestreich KJ, et al. Nat Immunol. 2014 Oct;15(10):957-64. doi: 10.1038/ni.2985. Epub 2014 Sep 7. Nat Immunol. 2014. PMID: 25194422 Free PMC article.
IL-7 signalling represses Bcl-6 and the TFH gene program.
McDonald PW, Read KA, Baker CE, Anderson AE, Powell MD, Ballesteros-Tato A, Oestreich KJ. McDonald PW, et al. Among authors: oestreich kj. Nat Commun. 2016 Jan 8;7:10285. doi: 10.1038/ncomms10285. Nat Commun. 2016. PMID: 26743592 Free PMC article.
46 results