Kern D - Search Results

1

From primordial clocks to circadian oscillators.

Pitsawong W, Pádua RAP, Grant T, Hoemberger M, Otten R, Bradshaw N, Grigorieff N, Kern D. Pitsawong W, et al. Among authors: kern d. Nature. 2023 Apr;616(7955):183-189. doi: 10.1038/s41586-023-05836-9. Epub 2023 Mar 22. Nature. 2023. PMID: 36949197 Free PMC article.

2

Probing microsecond time scale dynamics in proteins by methyl (1)H Carr-Purcell-Meiboom-Gill relaxation dispersion NMR measurements. Application to activation of the signaling protein NtrC(r).

Otten R, Villali J, Kern D, Mulder FA. Otten R, et al. Among authors: kern d. J Am Chem Soc. 2010 Dec 1;132(47):17004-14. doi: 10.1021/ja107410x. Epub 2010 Nov 8. J Am Chem Soc. 2010. PMID: 21058670 Free PMC article.

3

Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.

Agafonov RV, Wilson C, Otten R, Buosi V, Kern D. Agafonov RV, et al. Among authors: kern d. Nat Struct Mol Biol. 2014 Oct;21(10):848-53. doi: 10.1038/nsmb.2891. Epub 2014 Sep 14. Nat Struct Mol Biol. 2014. PMID: 25218445 Free PMC article.

4

The energy landscape of adenylate kinase during catalysis.

Kerns SJ, Agafonov RV, Cho YJ, Pontiggia F, Otten R, Pachov DV, Kutter S, Phung LA, Murphy PN, Thai V, Alber T, Hagan MF, Kern D. Kerns SJ, et al. Among authors: kern d. Nat Struct Mol Biol. 2015 Feb;22(2):124-31. doi: 10.1038/nsmb.2941. Epub 2015 Jan 12. Nat Struct Mol Biol. 2015. PMID: 25580578 Free PMC article.

5

Kinase dynamics. Using ancient protein kinases to unravel a modern cancer drug's mechanism.

Wilson C, Agafonov RV, Hoemberger M, Kutter S, Zorba A, Halpin J, Buosi V, Otten R, Waterman D, Theobald DL, Kern D. Wilson C, et al. Among authors: kern d. Science. 2015 Feb 20;347(6224):882-6. doi: 10.1126/science.aaa1823. Science. 2015. PMID: 25700521 Free PMC article.

6

Conformational Selection in a Protein-Protein Interaction Revealed by Dynamic Pathway Analysis.

Chakrabarti KS, Agafonov RV, Pontiggia F, Otten R, Higgins MK, Schertler GFX, Oprian DD, Kern D. Chakrabarti KS, et al. Among authors: kern d. Cell Rep. 2016 Jan 5;14(1):32-42. doi: 10.1016/j.celrep.2015.12.010. Epub 2015 Dec 24. Cell Rep. 2016. PMID: 26725117 Free PMC article.

7

Evolutionary drivers of thermoadaptation in enzyme catalysis.

Nguyen V, Wilson C, Hoemberger M, Stiller JB, Agafonov RV, Kutter S, English J, Theobald DL, Kern D. Nguyen V, et al. Among authors: kern d. Science. 2017 Jan 20;355(6322):289-294. doi: 10.1126/science.aah3717. Epub 2016 Dec 22. Science. 2017. PMID: 28008087 Free PMC article.

8

Rescue of conformational dynamics in enzyme catalysis by directed evolution.

Otten R, Liu L, Kenner LR, Clarkson MW, Mavor D, Tawfik DS, Kern D, Fraser JS. Otten R, et al. Among authors: kern d. Nat Commun. 2018 Apr 3;9(1):1314. doi: 10.1038/s41467-018-03562-9. Nat Commun. 2018. PMID: 29615624 Free PMC article.

9

Dynamics of human protein kinase Aurora A linked to drug selectivity.

Pitsawong W, Buosi V, Otten R, Agafonov RV, Zorba A, Kern N, Kutter S, Kern G, Pádua RA, Meniche X, Kern D. Pitsawong W, et al. Among authors: kern d, kern g, kern n. Elife. 2018 Jun 14;7:e36656. doi: 10.7554/eLife.36656. Elife. 2018. PMID: 29901437 Free PMC article.

10

Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2.

Pádua RAP, Sun Y, Marko I, Pitsawong W, Stiller JB, Otten R, Kern D. Pádua RAP, et al. Among authors: kern d. Nat Commun. 2018 Oct 30;9(1):4507. doi: 10.1038/s41467-018-06814-w. Nat Commun. 2018. PMID: 30375376 Free PMC article.

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