Effect of clofibrate on the chiral disposition of ibuprofen in rats.
Scheuerer S, Williams KM, Brugger R, McLachlan AJ, Brune K, Day RO, Geisslinger G.
Scheuerer S, et al. Among authors: day ro.
J Pharmacol Exp Ther. 1998 Mar;284(3):1132-8.
J Pharmacol Exp Ther. 1998.
PMID: 9495875
To determine whether this in vitro interaction is paralleled by a change in pharmacokinetics of ibuprofen in vivo two groups of rats were treated orally with clofibrate (n = 8, 280 mg/kg/day) or vehicle (n = 7) for 3 days. On day 3, 2 hr after the last dose of clofi …
To determine whether this in vitro interaction is paralleled by a change in pharmacokinetics of ibuprofen in vivo two groups of rats were tr …