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Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates.
Calvopiña K, Umland KD, Rydzik AM, Hinchliffe P, Brem J, Spencer J, Schofield CJ, Avison MB. Calvopiña K, et al. Among authors: spencer j. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4170-5. doi: 10.1128/AAC.00371-16. Print 2016 Jul. Antimicrob Agents Chemother. 2016. PMID: 27139464 Free PMC article.
Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
Hinchliffe P, González MM, Mojica MF, González JM, Castillo V, Saiz C, Kosmopoulou M, Tooke CL, Llarrull LI, Mahler G, Bonomo RA, Vila AJ, Spencer J. Hinchliffe P, et al. Among authors: spencer j. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3745-54. doi: 10.1073/pnas.1601368113. Epub 2016 Jun 14. Proc Natl Acad Sci U S A. 2016. PMID: 27303030 Free PMC article.
Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase.
González MM, Kosmopoulou M, Mojica MF, Castillo V, Hinchliffe P, Pettinati I, Brem J, Schofield CJ, Mahler G, Bonomo RA, Llarrull LI, Spencer J, Vila AJ. González MM, et al. Among authors: spencer j. ACS Infect Dis. 2015 Nov 13;1(11):544-54. doi: 10.1021/acsinfecdis.5b00046. Epub 2015 Jul 20. ACS Infect Dis. 2015. PMID: 27623409 Free PMC article.
Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.
Hinchliffe P, Yang QE, Portal E, Young T, Li H, Tooke CL, Carvalho MJ, Paterson NG, Brem J, Niumsup PR, Tansawai U, Lei L, Li M, Shen Z, Wang Y, Schofield CJ, Mulholland AJ, Shen J, Fey N, Walsh TR, Spencer J. Hinchliffe P, et al. Among authors: spencer j. Sci Rep. 2017 Jan 6;7:39392. doi: 10.1038/srep39392. Sci Rep. 2017. PMID: 28059088 Free PMC article.
3,111 results