Rabe P - Search Results

1

Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.

Hinchliffe P, Calvopiña K, Rabe P, Mojica MF, Schofield CJ, Dmitrienko GI, Bonomo RA, Vila AJ, Spencer J. Hinchliffe P, et al. Among authors: rabe p. J Biol Chem. 2023 May;299(5):104606. doi: 10.1016/j.jbc.2023.104606. Epub 2023 Mar 15. J Biol Chem. 2023. PMID: 36924941 Free PMC article.

2

Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2.

Liu X, Reinbold R, Liu S, Herold RA, Rabe P, Duclos S, Yadav RB, Abboud MI, Thieffine S, Armstrong FA, Brewitz L, Schofield CJ. Liu X, et al. Among authors: rabe p. J Biol Chem. 2023 Feb;299(2):102873. doi: 10.1016/j.jbc.2023.102873. Epub 2023 Jan 5. J Biol Chem. 2023. PMID: 36621625 Free PMC article.

3

Methods for production and assaying catalysis of isolated recombinant human aspartate/asparagine-β-hydroxylase.

Brewitz L, Brasnett A, Schnaubelt LI, Rabe P, Tumber A, Schofield CJ. Brewitz L, et al. Among authors: rabe p. Methods Enzymol. 2024;704:313-344. doi: 10.1016/bs.mie.2024.06.003. Epub 2024 Jun 29. Methods Enzymol. 2024. PMID: 39300654

4

Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.

Hinchliffe P, Calvopiña K, Rabe P, Mojica MF, Schofield CJ, Dmitrienko GI, Bonomo RA, Vila AJ, Spencer J. Hinchliffe P, et al. Among authors: rabe p. J Biol Chem. 2024 Oct;300(10):107819. doi: 10.1016/j.jbc.2024.107819. Epub 2024 Oct 9. J Biol Chem. 2024. PMID: 39383701 Free PMC article. No abstract available.

5

JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships.

Bonnici J, Oueini R, Salah E, Johansson C, Pires E, Abboud M, Dawber RS, Tumber A, Rabe P, Saraç H, Schofield CJ, Kawamura A. Bonnici J, et al. Among authors: rabe p. Commun Biol. 2024 Nov 27;7(1):1583. doi: 10.1038/s42003-024-07183-5. Commun Biol. 2024. PMID: 39604683 Free PMC article.

6

Biochemical and crystallographic studies of L,D-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate.

de Munnik M, Lang PA, Calvopiña K, Rabe P, Brem J, Schofield CJ. de Munnik M, et al. Among authors: rabe p. Commun Biol. 2024 Sep 18;7(1):1173. doi: 10.1038/s42003-024-06785-3. Commun Biol. 2024. PMID: 39294212 Free PMC article.

7

An E115A Missense Variant in CERS2 Is Associated With Increased Sleeping Energy Expenditure and Hepatic Insulin Resistance in American Indians.

Heinitz S, Traurig M, Krakoff J, Rabe P, Stäubert C, Kobes S, Hanson RL, Stumvoll M, Blüher M, Bogardus C, Baier L, Piaggi P. Heinitz S, et al. Among authors: rabe p. Diabetes. 2024 Aug 1;73(8):1361-1371. doi: 10.2337/db23-0690. Diabetes. 2024. PMID: 38776413

8

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane.

Frank N, Nugent J, Shire BR, Pickford HD, Rabe P, Sterling AJ, Zarganes-Tzitzikas T, Grimes T, Thompson AL, Smith RC, Schofield CJ, Brennan PE, Duarte F, Anderson EA. Frank N, et al. Among authors: rabe p. Nature. 2022 Nov;611(7937):721-726. doi: 10.1038/s41586-022-05290-z. Epub 2022 Sep 15. Nature. 2022. PMID: 36108675

9

Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.

Reinbold R, Hvinden IC, Rabe P, Herold RA, Finch A, Wood J, Morgan M, Staudt M, Clifton IJ, Armstrong FA, McCullagh JSO, Redmond J, Bardella C, Abboud MI, Schofield CJ. Reinbold R, et al. Among authors: rabe p. Nat Commun. 2022 Aug 15;13(1):4785. doi: 10.1038/s41467-022-32436-4. Nat Commun. 2022. PMID: 35970853 Free PMC article.

10

Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase.

Rabe P, Walla CC, Goodyear NK, Welsh J, Southwart R, Clifton I, Linyard JDS, Tumber A, Claridge TDW, Myers WK, Schofield CJ. Rabe P, et al. J Biol Chem. 2022 Sep;298(9):102249. doi: 10.1016/j.jbc.2022.102249. Epub 2022 Jul 11. J Biol Chem. 2022. PMID: 35835215 Free PMC article.

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