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Page 1
Structural basis of odorant recognition by a human odorant receptor.
Billesbølle CB, de March CA, van der Velden WJC, Ma N, Tewari J, Del Torrent CL, Li L, Faust B, Vaidehi N, Matsunami H, Manglik A. Billesbølle CB, et al. Among authors: van der velden wjc. Nature. 2023 Mar;615(7953):742-749. doi: 10.1038/s41586-023-05798-y. Epub 2023 Mar 15. Nature. 2023. PMID: 36922591 Free PMC article.
GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats.
van der Velden WJC, Smit FX, Christiansen CB, Møller TC, Hjortø GM, Larsen O, Schiellerup SP, Bräuner-Osborne H, Holst JJ, Hartmann B, Frimurer TM, Rosenkilde MM. van der Velden WJC, et al. ACS Pharmacol Transl Sci. 2021 Jan 19;4(1):296-313. doi: 10.1021/acsptsci.0c00193. eCollection 2021 Feb 12. ACS Pharmacol Transl Sci. 2021. PMID: 33615180 Free PMC article.
Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1.
Larsen O, Lückmann M, van der Velden WJC, Oliva-Santiago M, Brvar M, Ulven T, Frimurer TM, Karlshøj S, Rosenkilde MM. Larsen O, et al. Among authors: van der velden wjc. ACS Pharmacol Transl Sci. 2019 Nov 13;2(6):429-441. doi: 10.1021/acsptsci.9b00059. eCollection 2019 Dec 13. ACS Pharmacol Transl Sci. 2019. PMID: 32259075 Free PMC article.
Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system.
Gabe MBN, van der Velden WJC, Gadgaard S, Smit FX, Hartmann B, Bräuner-Osborne H, Rosenkilde MM. Gabe MBN, et al. Among authors: van der velden wjc. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):122-132. doi: 10.1111/bcpt.13289. Epub 2019 Aug 19. Basic Clin Pharmacol Toxicol. 2020. PMID: 31299132 Free PMC article.
Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2.
Ortiz Zacarías NV, van Veldhoven JPD, Portner L, van Spronsen E, Ullo S, Veenhuizen M, van der Velden WJC, Zweemer AJM, Kreekel RM, Oenema K, Lenselink EB, Heitman LH, IJzerman AP. Ortiz Zacarías NV, et al. Among authors: van der velden wjc, van spronsen e, van veldhoven jpd. J Med Chem. 2018 Oct 25;61(20):9146-9161. doi: 10.1021/acs.jmedchem.8b00605. Epub 2018 Oct 11. J Med Chem. 2018. PMID: 30256641 Free PMC article.
Engineered odorant receptors illuminate the basis of odour discrimination.
de March CA, Ma N, Billesbølle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H. de March CA, et al. Among authors: van der velden wjc. Nature. 2024 Nov;635(8038):499-508. doi: 10.1038/s41586-024-08126-0. Epub 2024 Oct 30. Nature. 2024. PMID: 39478229
Novel agonist and antagonist radioligands for the GLP-2 receptor. Useful tools for studies of basic GLP-2 receptor pharmacology.
Gadgaard S, van der Velden WJC, Schiellerup SP, Hunt JE, Gabe MBN, Windeløv JA, Boer GA, Kissow H, Ørskov C, Holst JJ, Hartmann B, Rosenkilde MM. Gadgaard S, et al. Among authors: van der velden wjc. Br J Pharmacol. 2022 May;179(9):1998-2015. doi: 10.1111/bph.15766. Epub 2022 Jan 11. Br J Pharmacol. 2022. PMID: 34855984 Free PMC article.
19 results