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Page 1
Allosteric targeting resolves limitations of earlier LFA-1 directed modalities.
Mancuso RV, Schneider G, Hürzeler M, Gut M, Zurflüh J, Breitenstein W, Bouitbir J, Reisen F, Atz K, Ehrhardt C, Duthaler U, Gygax D, Schmidt AG, Krähenbühl S, Weitz-Schmidt G. Mancuso RV, et al. Among authors: ehrhardt c. Biochem Pharmacol. 2023 May;211:115504. doi: 10.1016/j.bcp.2023.115504. Epub 2023 Mar 14. Biochem Pharmacol. 2023. PMID: 36921634
1,4-Diazepane-2-ones as novel inhibitors of LFA-1.
Wattanasin S, Albert R, Ehrhardt C, Roche D, Sabio M, Hommel U, Welzenbach K, Weitz-Schmidt G. Wattanasin S, et al. Among authors: ehrhardt c. Bioorg Med Chem Lett. 2003 Feb 10;13(3):499-502. doi: 10.1016/s0960-894x(02)00991-5. Bioorg Med Chem Lett. 2003. PMID: 12565959
1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.
Wattanasin S, Kallen J, Myers S, Guo Q, Sabio M, Ehrhardt C, Albert R, Hommel U, Weckbecker G, Welzenbach K, Weitz-Schmidt G. Wattanasin S, et al. Among authors: ehrhardt c. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1217-20. doi: 10.1016/j.bmcl.2004.11.072. Bioorg Med Chem Lett. 2005. PMID: 15686945
Decrypting Integrins by Mixed-Solvent Molecular Dynamics Simulations.
Ilie IM, Ehrhardt C, Caflisch A, Weitz-Schmidt G. Ilie IM, et al. Among authors: ehrhardt c. J Chem Inf Model. 2023 Jun 26;63(12):3878-3891. doi: 10.1021/acs.jcim.3c00480. Epub 2023 Jun 13. J Chem Inf Model. 2023. PMID: 37310029 Free PMC article.
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
Ostermann N, Ruedisser S, Ehrhardt C, Breitenstein W, Marzinzik A, Jacoby E, Vangrevelinghe E, Ottl J, Klumpp M, Hartwieg JC, Cumin F, Hassiepen U, Trappe J, Sedrani R, Geisse S, Gerhartz B, Richert P, Francotte E, Wagner T, Krömer M, Kosaka T, Webb RL, Rigel DF, Maibaum J, Baeschlin DK. Ostermann N, et al. Among authors: ehrhardt c. J Med Chem. 2013 Mar 28;56(6):2196-206. doi: 10.1021/jm301706j. Epub 2013 Mar 15. J Med Chem. 2013. PMID: 23360239
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.
Lorthiois E, Breitenstein W, Cumin F, Ehrhardt C, Francotte E, Jacoby E, Ostermann N, Sellner H, Kosaka T, Webb RL, Rigel DF, Hassiepen U, Richert P, Wagner T, Maibaum J. Lorthiois E, et al. Among authors: ehrhardt c. J Med Chem. 2013 Mar 28;56(6):2207-17. doi: 10.1021/jm3017078. Epub 2013 Mar 15. J Med Chem. 2013. PMID: 23425156
Trypsin inhibitors for the treatment of pancreatitis.
Brandl T, Simic O, Skaanderup PR, Namoto K, Berst F, Ehrhardt C, Schiering N, Mueller I, Woelcke J. Brandl T, et al. Among authors: ehrhardt c. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4340-4. doi: 10.1016/j.bmcl.2016.07.029. Epub 2016 Jul 17. Bioorg Med Chem Lett. 2016. PMID: 27476144
305 results