Kampourakis T - Search Results

1

In situ FRET-based localization of the N terminus of myosin binding protein-C in heart muscle cells.

Chandler J, Treacy C, Ameer-Beg S, Ehler E, Irving M, Kampourakis T. Chandler J, et al. Among authors: kampourakis t. Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2222005120. doi: 10.1073/pnas.2222005120. Epub 2023 Mar 13. Proc Natl Acad Sci U S A. 2023. PMID: 36913580 Free PMC article.

2

Regulatory domain of troponin moves dynamically during activation of cardiac muscle.

Sevrieva I, Knowles AC, Kampourakis T, Sun YB. Sevrieva I, et al. Among authors: kampourakis t. J Mol Cell Cardiol. 2014 Oct;75:181-7. doi: 10.1016/j.yjmcc.2014.07.015. Epub 2014 Aug 4. J Mol Cell Cardiol. 2014. PMID: 25101951 Free PMC article.

3

Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells.

Kampourakis T, Yan Z, Gautel M, Sun YB, Irving M. Kampourakis T, et al. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18763-8. doi: 10.1073/pnas.1413922112. Epub 2014 Dec 15. Proc Natl Acad Sci U S A. 2014. PMID: 25512492 Free PMC article.

4

Orientation of the N- and C-terminal lobes of the myosin regulatory light chain in cardiac muscle.

Kampourakis T, Sun YB, Irving M. Kampourakis T, et al. Biophys J. 2015 Jan 20;108(2):304-14. doi: 10.1016/j.bpj.2014.11.049. Biophys J. 2015. PMID: 25606679 Free PMC article.

5

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle.

Kampourakis T, Irving M. Kampourakis T, et al. J Mol Cell Cardiol. 2015 Aug;85:199-206. doi: 10.1016/j.yjmcc.2015.06.002. Epub 2015 Jun 7. J Mol Cell Cardiol. 2015. PMID: 26057075 Free PMC article.

6

Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments.

Kampourakis T, Sun YB, Irving M. Kampourakis T, et al. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3039-47. doi: 10.1073/pnas.1602776113. Epub 2016 May 9. Proc Natl Acad Sci U S A. 2016. PMID: 27162358 Free PMC article.

7

Reversible Covalent Binding to Cardiac Troponin C by the Ca²⁺-Sensitizer Levosimendan.

Robertson IM, Pineda-Sanabria SE, Yan Z, Kampourakis T, Sun YB, Sykes BD, Irving M. Robertson IM, et al. Among authors: kampourakis t. Biochemistry. 2016 Nov 1;55(43):6032-6045. doi: 10.1021/acs.biochem.6b00758. Epub 2016 Oct 17. Biochemistry. 2016. PMID: 27673371

8

Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle.

Zhang X, Kampourakis T, Yan Z, Sevrieva I, Irving M, Sun YB. Zhang X, et al. Among authors: kampourakis t. Elife. 2017 Feb 23;6:e24081. doi: 10.7554/eLife.24081. Elife. 2017. PMID: 28229860 Free PMC article.

9

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament.

Kampourakis T, Zhang X, Sun YB, Irving M. Kampourakis T, et al. J Physiol. 2018 Jan 1;596(1):31-46. doi: 10.1113/JP275050. Epub 2017 Nov 21. J Physiol. 2018. PMID: 29052230 Free PMC article.

10

Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle.

Kampourakis T, Ponnam S, Irving M. Kampourakis T, et al. J Mol Cell Cardiol. 2018 Apr;117:72-81. doi: 10.1016/j.yjmcc.2018.02.009. Epub 2018 Feb 13. J Mol Cell Cardiol. 2018. PMID: 29452157 Free PMC article.

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