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309 results

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Page 1
[18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data.
Ballweg A, Klaus C, Vogler L, Katzdobler S, Wind K, Zatcepin A, Ziegler SI, Secgin B, Eckenweber F, Bohr B, Bernhardt A, Fietzek U, Rauchmann BS, Stoecklein S, Quach S, Beyer L, Scheifele M, Simmet M, Joseph E, Lindner S, Berg I, Koglin N, Mueller A, Stephens AW, Bartenstein P, Tonn JC, Albert NL, Kümpfel T, Kerschensteiner M, Perneczky R, Levin J, Paeger L, Herms J, Brendel M. Ballweg A, et al. Among authors: bernhardt a. J Neuroinflammation. 2023 Mar 11;20(1):68. doi: 10.1186/s12974-023-02749-2. J Neuroinflammation. 2023. PMID: 36906584 Free PMC article.
Association of Neurofilament Light Chain, [18F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS.
Palleis C, Franzmeier N, Weidinger E, Bernhardt AM, Katzdobler S, Wall S, Ferschmann C, Harris S, Schmitt J, Schuster S, Gnörich J, Finze A, Biechele G, Lindner S, Albert NL, Bartenstein P, Sabri O, Barthel H, Rupprecht R, Nuscher B, Stephens AW, Rauchmann BS, Perneczky R, Haass C, Brendel M, Levin J, Höglinger GU. Palleis C, et al. Among authors: bernhardt am. Neurology. 2024 Jan 9;102(1):e207901. doi: 10.1212/WNL.0000000000207901. Epub 2023 Dec 14. Neurology. 2024. PMID: 38165362
Subcortical tau is linked to hypoperfusion in connected cortical regions in 4-repeat tauopathies.
Roemer SN, Brendel M, Gnörich J, Malpetti M, Zaganjori M, Quattrone A, Gross M, Steward A, Dewenter A, Wagner F, Dehsarvi A, Ferschmann C, Wall S, Palleis C, Rauchmann BS, Katzdobler S, Jäck A, Stockbauer A, Fietzek UM, Bernhardt AM, Weidinger E, Zwergal A, Stöcklein S, Perneczky R, Barthel H, Sabri O, Levin J, Höglinger GU, Franzmeier N. Roemer SN, et al. Among authors: bernhardt am. Brain. 2024 Jul 5;147(7):2428-2439. doi: 10.1093/brain/awae174. Brain. 2024. PMID: 38842726
Risk willingness in multiple system atrophy and Parkinson's disease understanding patient preferences.
Bernhardt AM, Oeller M, Friedrich I, Kocakavuk E, Nachman E, Peikert K, Roderigo M, Rossmann A, Schröter T, Wilhelm LO, Prell T, van Riesen C, Nieweler J, Katzdobler S, Weiler M, Jacobi H, Warnecke T, Claus I, Palleis C, Breimann S, Falkenburger B, Brandt M, Hermann A, Rumpf JJ, Claßen J, Höglinger G, Gandor F, Levin J, Giese A, Janzen A, Oertel WH. Bernhardt AM, et al. NPJ Parkinsons Dis. 2024 Aug 15;10(1):158. doi: 10.1038/s41531-024-00764-5. NPJ Parkinsons Dis. 2024. PMID: 39147806 Free PMC article.
GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA).
Katzdobler S, Nübling G, Klietz M, Fietzek UM, Palleis C, Bernhardt AM, Wegner F, Huber M, Rogozinski S, Schneider LS, Spruth EJ, Beyle A, Vogt IR, Brandt M, Hansen N, Glanz W, Brockmann K, Spottke A, Hoffmann DC, Peters O, Priller J, Wiltfang J, Düzel E, Schneider A, Falkenburger B, Klockgether T, Gasser T, Nuscher B, Haass C, Höglinger G, Levin J. Katzdobler S, et al. Among authors: bernhardt am. J Neurol. 2024 Oct;271(10):6991-6999. doi: 10.1007/s00415-024-12647-z. Epub 2024 Sep 10. J Neurol. 2024. PMID: 39254698 Free PMC article.
Combining cerebrospinal fluid and PI-2620 tau-PET for biomarker-based stratification of Alzheimer's disease and 4R-tauopathies.
Dilcher R, Wall S, Groß M, Katzdobler S, Wagemann O, Palleis C, Weidinger E, Fietzek U, Bernhardt A, Kurz C, Ferschmann C, Scheifele M, Zaganjori M, Gnörich J, Bürger K, Janowitz D, Rauchmann BS, Stöcklein S, Bartenstein P, Villemagne V, Seibyl J, Sabri O, Barthel H, Perneczky R, Schöberl F, Zwergal A, Höglinger GU, Levin J, Franzmeier N, Brendel M. Dilcher R, et al. Among authors: bernhardt a. Alzheimers Dement. 2024 Oct;20(10):6896-6909. doi: 10.1002/alz.14185. Epub 2024 Sep 12. Alzheimers Dement. 2024. PMID: 39263969 Free PMC article.
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies.
Slemann L, Gnörich J, Hummel S, Bartos LM, Klaus C, Kling A, Kusche-Palenga J, Kunte ST, Kunze LH, Englert AL, Li Y, Vogler L, Katzdobler S, Palleis C, Bernhardt A, Jäck A, Zwergal A, Hopfner F, Roemer-Cassiano SN, Biechele G, Stöcklein S, Bischof G, van Eimeren T, Drzezga A, Sabri O, Barthel H, Respondek G, Grimmer T, Levin J, Herms J, Paeger L, Willroider M, Beyer L, Höglinger GU, Roeber S, Franzmeier N, Brendel M. Slemann L, et al. Among authors: bernhardt a. Acta Neuropathol. 2024 Nov 24;148(1):70. doi: 10.1007/s00401-024-02834-7. Acta Neuropathol. 2024. PMID: 39580770 Free PMC article.
A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases.
Bernhardt AM, Tiedt S, Teupser D, Dichgans M, Meyer B, Gempt J, Kuhn PH, Simons M, Palleis C, Weidinger E, Nübling G, Holdt L, Hönikl L, Gasperi C, Giesbertz P, Müller SA, Breimann S, Lichtenthaler SF, Kuster B, Mann M, Imhof A, Barth T, Hauck SM, Zetterberg H, Otto M, Weichert W, Hemmer B, Levin J. Bernhardt AM, et al. EBioMedicine. 2023 Mar;89:104456. doi: 10.1016/j.ebiom.2023.104456. Epub 2023 Feb 4. EBioMedicine. 2023. PMID: 36745974 Free PMC article. Review.
α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden.
Levin J, Baiardi S, Quadalti C, Rossi M, Mammana A, Vöglein J, Bernhardt A, Perrin RJ, Jucker M, Preische O, Hofmann A, Höglinger GU, Cairns NJ, Franklin EE, Chrem P, Cruchaga C, Berman SB, Chhatwal JP, Daniels A, Day GS, Ryan NS, Goate AM, Gordon BA, Huey ED, Ibanez L, Karch CM, Lee JH, Llibre-Guerra J, Lopera F, Masters CL, Morris JC, Noble JM, Renton AE, Roh JH, Frosch MP, Keene CD, McLean C, Sanchez-Valle R, Schofield PR, Supnet-Bell C, Xiong C, Giese A, Hansson O, Bateman RJ, McDade E; Dominantly Inherited Alzheimer Network; Parchi P. Levin J, et al. Among authors: bernhardt a. Alzheimers Dement. 2024 Jun;20(6):4351-4365. doi: 10.1002/alz.13818. Epub 2024 Apr 26. Alzheimers Dement. 2024. PMID: 38666355 Free PMC article.
309 results