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The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J.
Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot JD, Matuskey D, Mecca AP, Pittman B, Dias M, Nabulsi NB, Finnema SJ, Chen MK, Arnsten A, Radhakrishnan R, Skosnik PD, D'Souza DC, Esterlis I, Huang Y, van Dyck CH, Carson RE. Toyonaga T, et al. Among authors: pittman b. Eur J Nucl Med Mol Imaging. 2024 Mar;51(4):1012-1022. doi: 10.1007/s00259-023-06487-8. Epub 2023 Nov 13. Eur J Nucl Med Mol Imaging. 2024. PMID: 37955791
11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults.
Matuskey D, Yang Y, Naganawa M, Koohsari S, Toyonaga T, Gravel P, Pittman B, Torres K, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal LH, Franke CJ, Walicki BM, Esterlis I, Skosnik P, Radhakrishnan R, Wolf JM, Nabulsi N, Ropchan J, Huang Y, Carson RE, Naples AJ, McPartland JC. Matuskey D, et al. Among authors: pittman b. Mol Psychiatry. 2024 Oct 4. doi: 10.1038/s41380-024-02776-2. Online ahead of print. Mol Psychiatry. 2024. PMID: 39367053
312 results