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Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma.
Rajendran S, Hu Y, Canella A, Peterson C, Gross A, Cam M, Nazzaro M, Haffey A, Serin-Harmanci A, Distefano R, Nigita G, Wang W, Kreatsoulas D, Li Z, Sepeda JA, Sas A, Hester ME, Miller KE, Elemento O, Roberts RD, Holland EC, Rao G, Mardis ER, Rajappa P. Rajendran S, et al. Among authors: holland ec. Cell Rep. 2023 Mar 28;42(3):112197. doi: 10.1016/j.celrep.2023.112197. Epub 2023 Mar 3. Cell Rep. 2023. PMID: 36871221 Free article.
ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models.
Schmid S, Russell ZR, Yamashita AS, West ME, Parrish AG, Walker J, Rudoy D, Yan JZ, Quist DC, Gessesse BN, Alvinez N, Hill KD, Anderson LW, Cimino PJ, Kumasaka DK, Parchment RE, Holland EC, Szulzewsky F. Schmid S, et al. Among authors: holland ec. Cell Rep. 2024 Oct 22;43(10):114829. doi: 10.1016/j.celrep.2024.114829. Epub 2024 Oct 3. Cell Rep. 2024. PMID: 39365700 Free PMC article.
Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.
Thirimanne HN, Almiron-Bonnin D, Nuechterlein N, Arora S, Jensen M, Parada CA, Qiu C, Szulzewsky F, English CW, Chen WC, Sievers P, Nassiri F, Wang JZ, Klisch TJ, Aldape KD, Patel AJ, Cimino PJ, Zadeh G, Sahm F, Raleigh DR, Shendure J, Ferreira M, Holland EC. Thirimanne HN, et al. Among authors: holland ec. Cell Genom. 2024 Jun 12;4(6):100566. doi: 10.1016/j.xgen.2024.100566. Epub 2024 May 23. Cell Genom. 2024. PMID: 38788713 Free PMC article.
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.
Nuechterlein N, Shelbourn A, Szulzewsky F, Arora S, Casad M, Pattwell S, Merino-Galan L, Sulman E, Arowa S, Alvinez N, Jung M, Brown D, Tang K, Jackson S, Stoica S, Chittaboina P, Banasavadi-Siddegowda YK, Wirsching HG, Stella N, Shapiro L, Paddison P, Patel AP, Gilbert MR, Abdullaev Z, Aldape K, Pratt D, Holland EC, Cimino PJ. Nuechterlein N, et al. Among authors: holland ec. Genes Dev. 2024 Apr 17;38(5-6):273-288. doi: 10.1101/gad.351350.123. Genes Dev. 2024. PMID: 38589034 Free PMC article.
HOXD12 defines an age-related aggressive subtype of oligodendroglioma.
Nuechterlein N, Cimino S, Shelbourn A, Ha V, Arora S, Rajan S, Shapiro LG, Holland EC, Aldape K, McGranahan T, Gilbert MR, Cimino PJ. Nuechterlein N, et al. Among authors: holland ec. Acta Neuropathol. 2024 Sep 11;148(1):41. doi: 10.1007/s00401-024-02802-1. Acta Neuropathol. 2024. PMID: 39259414 Free PMC article.
274 results